Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 Case.

Background: Listeriosis, a severe foodborne infection caused by , poses significant risks during pregnancy, including maternal-neonatal transmission. This study describes the clinical and genomic characteristics of an sequence type 8 (ST8) strain involved in maternal-neonatal transmission during pregnancy.

Methods: Clinical presentation, diagnostic process, and treatment outcomes of the case were documented in detail.

Circular RNA Circ_0002762 promotes cell migration and invasion in cervical squamous cell carcinoma via activating RelA/nuclear factor kappa B (nf-kB) signaling pathway.

Cervical cancer is a leading cause of cancer-related deaths, with cervical squamous cell carcinoma (CSCC) accounting for a majority of cases. Circular RNAs (circRNAs) have been repeatedly suggested as crucial effectors in modulating development of multiple malignancies. The expression of circ_0002762 was predicted to be high in CSCC tissues in GEO dataset, but the functional role and underlying regulatory mechanism of circ_0002762 in CSCC was unclear.

Green Syngas from Photothermal Catalytic Cellulose Steam Reforming on Ni/SiO Nanocatalysts: Synergy of La Promotion and Ni-O Photoactivation.

Replacing fossil fuels by renewable biomass enables green syngas production in an effort to achieve carbon neutrality and sustainable circular processes. Here, an inexpensive catalyst of Ni nanoparticles supported on SiO modified by La (Ni/La-S) is presented, exhibiting exceptional H and CO production rates (4051.4 and 2467.

Landscape of the intratumoral microbiota acting on the tumor immune microenvironment in LUAD and LUSC.

While the intratumoral microbiota has been discovered to have a close connection with tumor immunity, the specific role played by intratumoral microbiota in regulating the tumor immune microenvironment (TIME) of lung cancer remains largely unexplored. Here, we comprehensively investigated the association between intratumoral microbiota and the TIME in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). First, we found that intratumoral microbiota and host transcriptome profile significantly differed between LUAD and LUSC.

Identification of Schizophrenia-Risk Regulatory Variant rs1399178 in the Non-coding Region With Its Impact on NRF1 Binding.

Aims: The challenges in identifying functional variants from genome-wide association studies (GWAS) and unraveling regulatory mechanisms in schizophrenia research persist, particularly in intronic regions. A non-coding regulatory variant, rs1399178, associated with schizophrenia risk, is identified and its impact on NRF1 binding is investigated.

Methods: This study focuses on schizophrenia GWAS risk loci, using functional genomics, expression analyses and structural analysis to identify 736 schizophrenia risk single-nucleotide polymorphisms (SNPs) that disrupt transcription factor (TF) binding.

Identification, Genome Characterization, and Growth Optimization of MHJL1 for Biocontrol and Growth Promotion of Cotton Seedlings.

Fusarium and verticillium wilt are the primary diseases affecting cotton plants, significantly reducing both the yield and quality of cotton. spp. are crucial biocontrol strains for controlling plant diseases.

Exploring the causal associations of gout and serum uric acid levels on erectile dysfunction: A Mendelian randomization study.

Several observational studies have suggested a possible link between gout, serum uric acid (UA) levels, and erectile dysfunction (ED). Nonetheless, the current body of evidence does not allow for a conclusive determination regarding the influence of gout and serum UA on the likelihood of developing ED. The primary aim of this research was to explore the potential causal relationship between gout and serum UA levels in relation to ED utilizing Mendelian randomization (MR) analysis.

Alterations in gut microbiota in Rheumatoid arthritis patients with interstitial lung Disease: A Comparative study.

Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is considered one of the most severe complications of rheumatoid arthritis. The etiology of RA-ILD is complex, involving genetic and environmental factors. Recent studies suggest that the gut microbiota, a critical component of the immune system, may influence the pathogenesis of RA and other autoimmune disorders.

A new wave of resurgence for GII.4 Sydney in Huzhou, particularly GII.4 Sydney[P16], between 2019 and 2023.

Background: Norovirus (NoV) infection is a major pathogen causing acute gastroenteritis (AGE) across all age groups worldwide. In the past few years, there were some situations where non-GII.4 genotypes of NoV became predominant in Huzhou region.

Avian Migration-Mediated Transmission and Recombination Driving the Diversity of Gammacoronaviruses and Deltacoronaviruses.

In the wake of pandemics like COVID-19, which have zoonotic origins, the role of wildlife as reservoirs for emerging infectious diseases has garnered heightened attention. Migratory birds, traversing continents, represent a potent but under-researched vector for the spread of infectious diseases, including novel coronaviruses. This study delves into the genetic diversity and transmission dynamics of coronaviruses in migratory birds, presenting pivotal findings.

B←N Lewis Pair-Functionalized Perylenes: Tuning Optoelectronic Properties via Regioisomerization.

Herein, we report two -regioisomers of B←N Lewis pair-functionalized perylenes: the centrosymmetric and the mirror-symmetric . Mirror-symmetric functionalization more effectively tunes the photoelectronic properties. The LUMO energy levels of and are stabilized to -3.

Highly Sensitive and Selective Detection of Uranyl Ions Based on a Tb-Functionalized MOF via Competitive Host-Guest Coordination.

Owing to the rapid development of the nuclear industry, uranium has become a global environmental contaminant due to its radiotoxicity and chemotoxicity, posing significant threats to human health and ecological safety. Although various instrumental and chemical analytical methods have been developed for uranyl ion detection in aquatic environments, searching for new sensors with high stability, sensitivity, and selectivity remains a challenge. In this study, a luminescent Zr-based metal-organic framework (MOF), designated as Tb@UiO-66-(COOH), was successfully synthesized utilizing a postsynthetic exchange (PSE) method along with Tb ion doping for uranyl ion detection.

Whole-genome sequence analysis of SFTS bunyavirus in Huzhou, China.

Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne emerging infectious disease caused by SFTS virus (SFTSV), is a growing public health threat due to its high mortality rate. To understand the genomic characteristics of SFTSV samples isolated in Huzhou, China, the full-length genomes of Huzhou SFTSV isolates obtained between February 1, 2019 and December 30, 2023 were sequenced, and the gene loci, evolution, and sequence identity of the genome sequences were analyzed using MEGA. The complete genome sequences of seven SFTSV samples were obtained successfully.

Heterointerface magic: How FeS/NiS@NC nanoparticles transform sodium-ion battery anode performance.

Transition metal sulfides (TMS) are acknowledged as potential anode materials for sodium ion batteries (SIBs); however, their practical application is significantly hindered by suboptimal cycling durability and inadequate rate performance, primarily stemming from limited electronic conductivity and substantial volume swelling during the sodiation/desodiation process. Constructing heterojunction incorporating multiple active components has been emerged as an effective strategy to mitigate these limitations. In this study, high lattice matching FeS/NiS heterojunction nanoparticles anchored on a carbon skeleton (FeS/NiS@NC) were synthesized by a facile high-temperature pyrolysis and sulfidation process.

Interactions between ABC gene polymorphisms and processing speed in predicting depression severity.

Background: ABC family genes encode ATP-binding cassette proteins, which are involved in the transport of various substances and are associated with major depressive disorder (MDD); however, their clinical significance in MDD remains unclear. Therefore, this study aimed to investigate whether ABC family genes are associated with cognitive function, and the combined effects of genes and cognitive function on the severity of depression.

Method: Linear models or logistic regression models were used to investigate the associations of ABC family gene variants with clinical symptoms and cognitive function in 805 MDD patients (12-65 years old) and 1493 age-matched healthy controls (HCs).

Intratumoral microbiota, fatty acid metabolism, and tumor microenvironment constitute an unresolved trinity in colon adenocarcinoma.

The intratumoral microbiota, fatty acid metabolism (FAM), and tumor microenvironment (TME) all provide insights into the management of colon adenocarcinoma (COAD). But the biological link among the three remains unclear. Here, we analyzed intratumoral microbiome samples and matched host transcriptome samples from 420 patients with COAD in The Cancer Genome Atlas (TCGA).

Association of quality of life in older patients with breast cancer: a cross-sectional study from China.

Objectives: The purpose of this study was to investigate the quality of life (QoL) of older Chinese patients with breast cancer and to explore further the associations of functions, symptoms, financial burdens and comorbidities with global health/quality of life (gQoL).

Design: This was a cross-sectional study carried out following the Strengthening the Reporting of Observational Studies in Epidemiology checklist.

Setting: This study was conducted in two hospitals in Beijing from October 2021 to November 2022.

Prognostic stratification of gastric cancer patients by intratumoral microbiota-mediated tumor immune microenvironment.

Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced GC are limited. Here, we observe that intratumoral microbiota controls chemokine expression, which in turn recruits immune cells into the tumor, and that immune infiltration is strongly associated with patient survival and disease attributes. Furthermore, microbiota regulation of chemokines is differentiated in GC patients with different survival risks.

Tumor-colonizing Lachnoclostridium-mediated chemokine expression enhances the immune infiltration of bladder urothelial carcinoma.

Limited research into the tumor immune microenvironment (TIME) for bladder urothelial carcinoma (BUC), particularly the neglect of the intratumoral microbiota, has hindered the development of immunotherapies targeting BUC. Here, we collect 401 patients with BUC with host transcriptome samples and matched tumor microbiome samples from The Cancer Genome Atlas database. Besides, two independent BUC cohorts receiving immunotherapy were obtained.

Growth-promoting effects of self-selected microbial community on wheat seedlings in saline-alkali soil environments.

Saline-alkali land is a type of soil environment that causes poor crop growth and low yields. Its management and utilization are, therefore of great significance for increasing arable land resources, ensuring food security, and enhancing agricultural production capacity. The application of plant growth-promoting rhizobacteria (PGPR) is an effective way to promote the establishment of symbiotic relationships between plants and the rhizosphere microenvironment, plant growth and development, and plant resistance to saline-alkali stress.

Molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli Isolates from Patients and raw meat in Huzhou, China, 2021-2022.

Background: Campylobacter species are zoonotic pathogens, and are considered to be the major foodborne pathogen that causes outbreaks and sporadic gastrointestinal illnesses both in developed and developing countries. In this study, the molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli isolates from patients and raw meat between 2021 and 2022 in Huzhou were analyzed by using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST) and antimicrobial susceptibility testing.

Methods: From September 1, 2021 to December 31, 2022, a total of 342 fecal specimens from diarrheal patients at a sentinel hospital in Huzhou and 168 samples of raw meat products collected from farmers' markets and supermarkets, were subjected to Campylobacter isolation and identification.