Publications by authors named "Lei Hong"

Using deep eutectic solvents (DES) to pretreat wheat straw (WS) and extract lignin-containing nanocellulose (LCNC). Acrylic acid/choline chloride (AA/ChCl) polymerizable deep eutectic solvents (PDES) were used as the primary polymerization network, combined with polyvinyl alcohol (PVA). Lignocellulose nanocrystals (LCNC) oxidized by sodium periodate were prepared as dialdehyde-based nanocellulose (DCNC) to serve as the crosslinking agent.

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Breast cancer represents a significant health burden globally, necessitating ongoing advancements in treatment strategies for improved patient outcomes. Immunotherapy, particularly targeting immune checkpoints like programmed death-1 (PD-1), has emerged as a promising approach in cancer therapy. This study focuses on elucidating the role of PD-1 in modulating the IFN-γ-CXCL9/10-CXCR3 signaling axis within the breast cancer microenvironment.

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  • Water-soluble poly(vinyl alcohol) (PVA) has potential as an eco-friendly adhesive but struggles with water and mildew resistance in the wood industry.
  • Researchers synthesized a polyester-type PVA adhesive (CPVA) using PVA and citric acid, which improved its bonding performance, water resistance, and anti-mildew properties.
  • The CPVA adhesive met performance standards and showed good bonding with plywood and metals, making it a viable alternative for creating formaldehyde-free wood composites.
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  • The study developed an intranasal COVID-19 vaccine called RBD-HR, which consists of a receptor binding domain-derived protein and a special oil-in-water adjuvant for enhanced immune response.
  • Testing in mice and rats showed that the vaccine generated strong and long-lasting immune responses, producing high levels of neutralizing antibodies against specific SARS-CoV-2 variants for at least six months.
  • Additionally, the intranasal administration of the vaccine resulted in effective mucosal and systemic immunity, and when used as a booster after mRNA vaccines, it provided better immune responses and protection against live virus challenges.
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Due to the innate recalcitrancy caused by robust hydrogen bonding interaction, cellulose cannot be easily processed into high-valued materials or chemicals. Herein, a solvent-free ball milling treatment was conducted to activate microcrystalline cellulose (MCC). The research results demonstrated that ball milling treatment rapidly reduced the average particle size (Ð) and crystalline index (CrI) of MCC.

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The present study investigated the effects of water extracts of L. (WEAA) on rumen immune and antioxidative indexes, fermentation parameters and microbial diversity in lambs. A total of 32 3-month-old Dorper × Han female lambs having comparable body weights (24±0.

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  • Biomass-based non-isocyanate polyurethane (NIPU) is gaining attention in the polyurethane industry for its sustainable materials and lack of toxic isocyanates.
  • This study focuses on lignin, a renewable natural polymer, to create lignin-based NIPU (L-NIPU) foams using maleic acid as an initiator and glutaraldehyde as a cross-linker, producing lightweight and strong materials.
  • The optimal composition of 18% maleic acid and 25% glutaraldehyde yields foams with significant compressive strength (up to 0.5 MPa) and low thermal conductivity (0.03559 W/m·K), making them suitable for insulation in construction
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  • - The study focuses on creating a new wood adhesive called OCHU, made from oxidized cellulose combined with hexamethylene diamine and urea, which shows high bonding strength and excellent water resistance.
  • - To enhance the cellulose, it undergoes enzymatic hydrolysis and oxidation, increasing its solubility and the number of reactive groups, leading to better adhesive properties.
  • - The OCHU adhesive proves its effectiveness with significantly improved wet strength—60% stronger than its predecessor (OCH)—and shows potential for widespread use in the plywood industry due to its superior performance.
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Two novel conjugated polymers (polymer 1 and polymer 2) containing trisheterocyclic systems and carbazole as the copolymerization unit were synthesized by the Suzuki coupling reaction and characterized using NMR spectroscopy and other methods. 4'-(3,5-Dibromophenyl)-2,2':6',2''-terpyridine and 2,2'-(4-(3,5-dibromophenyl)pyridine-2,6-diyl)dithiazole were used as the recognizing units of the two polymers respectively. The polymers show blue-violet fluorescence when dissolved in THF.

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Autosomal recessive spinocerebellar ataxias (SCARs) are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation (c.

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  • Early detection of cancer is vital, and this study introduces an innovative portable device called ePAD for detecting tumor markers like alpha-fetoprotein (AFP) at very low levels.
  • The ePAD uses advanced hollow nanoboxes made of copper/cuprous sulfide and gold nanoparticles to enhance the detection process and incorporates sliding microfluidic paper chips to ensure flexibility and sensitivity.
  • Test results showed the device can accurately detect AFP levels in human serum, matching results from standard methods, thus proving its potential for quick, reliable on-site cancer diagnosis.
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  • Soluble factors in the upper respiratory tract, specifically a protease called HAT, can help defend against SARS-CoV-2 by reducing its infectivity through cleavage of the virus's spike protein.
  • In studies, infected mice showed increased levels of HAT, which effectively blocked the virus's ability to attach to and fuse with host cells.
  • However, HAT was found to be less effective against the Delta and certain Omicron variants due to mutations near the cleavage site that rendered it resistant.
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Colorectal cancer is the third most common cancer and the second most lethal cancer in the world. The main cause of the disease is due to dietary and behavioral factors. The treatment of this complex disease is mainly based on traditional treatments, including surgery, radiotherapy, and chemotherapy.

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Renal fibrosis is a process in which excessive deposition of extracellular matrix leads to an increase in tissue hardness and gradual destruction of the renal parenchyma. Chronic kidney disease (CKD) commonly progresses to end-stage renal disease (ESRD), ultimately leading to renal failure. This disease has high incidence and mortality rates, but to date, effective treatment options are lacking.

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It is generally recognized that the quality differences in plant germplasm resources are genetically determined, and that only a good "pedigree" can have good quality. Ecological memory of plants and rhizosphere soil fungi provides a new perspective to understand this phenomenon. Here, we selected 45 tea tree germplasm resources and analyzed the rhizosphere soil fungi, nutrient content and tea quality.

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Background: Cell subsets differentially modulate host immune responses to Mycobacterium tuberculosis (MTB) infection. However, the nature and functions of these subsets against osteoarticular tuberculosis (OTB) are unclear. Here, we aimed to understand the phenotypes and functions of immune cell subsets in patients with OTB using single-cell RNA sequencing (scRNA-Seq).

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  • - Aerospace breeding is a technique that uses spacecraft to enhance plant mutation for identifying superior varieties, specifically in this study focused on tea trees subjected to aviation mutagenesis (TM) compared to a control group (CK).
  • - Results indicated that TM tea trees had larger leaves and superior growth and photosynthetic rates compared to CK, alongside increased resistance indicators such as higher levels of enzymes like superoxide dismutase.
  • - Hormonal analysis revealed four key hormones (l-tryptophan, indole, salicylic acid, and salicylic acid 2--β-glucoside) were more abundant in TM trees, positively correlating with growth and yield, and their application significantly boosted growth metrics in seedlings. *
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Background: Self-emulsifying nano-phase of traditional Chinese medicine are a research hotspot. Xiao-Chai-Hu decoction is a commonly used compound decoction in clinical practice, which is of great research significance. The aim of this study was to isolate and characterize the self-emulsifying nano-phase and other phases of Xiao-Chai-Hu decoction, and to study the effects of each phase on acute liver injury.

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Nucleophosmin 1 (NPM1) is commonly mutated in myelodysplastic syndrome (MDS) and acute myeloid leukemia. Concurrent inflammatory bowel diseases (IBD) and MDS are common, indicating a close relationship between IBD and MDS. Here we examined the function of NPM1 in IBD and colitis-associated colorectal cancer (CAC).

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Light-induced ligand-to-metal charge transfer (LMCT) has been utilized as a powerful strategy in various organic reactions. First-row transition metals, especially iron complexes, show good applications in this process. Fe(III)-Cl and Fe(III)-OR species are two key intermediates involved in the LMCT of iron complexes.

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  • * The improved adhesive system significantly increased the bonding strength of plywood and particleboard, showing percentage increases of 15-17% when dry and up to 82% after boiling for particleboard, and 37% to 90% for plywood at various tests.
  • * Key reasons for increased strength included a more controlled cross-linking process, higher pH shifting the polycondensation equilibrium, and enhanced interaction between the adhesive and wood at the molecular level.
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