Publications by Lei Guang Cui

Publications by authors named "Lei Guang Cui"

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Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer.

Bong-Kook Ko Soyoung Choi Lei Guang Cui Young-Ha Lee In-Sik Hwang

PLoS One

May 2016

Anti-HER2 murine monoclonal antibody 1E11 has strong and synergistic anti-tumor activity in HER2-overexpressing gastric cancer cells when used in combination with trastuzumab. We presently optimized this antibody for human therapeutics. First, the complementarity determining regions (CDRs) of the murine antibody were grafted onto human germline immunoglobulin variable genes.

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