Pomegranate-like multicore-shell MnO encapsulated mesoporous N-doped carbon nanospheres with an internal void space for high-performance lithium-ion batteries.

A new class of pomegranate-like multicore-shell Mn3O4 encapsulated mesoporous N-doped carbon nanospheres (m-N-C@Mn3O4) with an internal void space has been developed. The novel nanostructure of m-N-C@Mn3O4 nanopomegranates has been proven to significantly alleviate the volume change and improve the electronic conductivity, which endows lithium-ion batteries with superior rate performance and cycling stability.

mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients.

Background: Splicing factor 3b subunit 1 (), a splicing factor modulating RNA alternative splicing, is frequently mutated in multiple hematological malignancies including myelodysplastic syndromes and chronic lymphocytic leukemia (CLL). The clinical impact of mutation on CLL remains controversial especially for patients of Asian descent.

Methods: We retrospectively analyzed the frequency of mutation by Sanger sequencing in 399 newly diagnosed Chinese CLL patients.

Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis.

Circular RNAs (circRNAs) have recently been reported to play crucial roles in various regulatory processes and involved in cancer onset and progression. However, the potential mechanism of circRNAs in chronic lymphocytic leukemia (CLL) remains largely unknown. Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR-337-3p (miR-337-3p) and regulate its activity, which resulted in a downstream change of target-gene PML and a consequent influence on cell viability.

MnO microspheres as an oxidase mimic for rapid detection of glutathione.

Exploiting a rapid and sensitive method for biomarker detection has important implications in the early diagnosis of diseases. Here, we synthesized MnO microspheres which worked as a nanozyme to exhibit outstanding oxidase-like activity for rapid colorimetric determination of glutathione (GSH). The MnO microspheres of about 800 nm in size could be prepared through a hydrothermal method, and we found that the as-prepared MnO microspheres could quickly oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to its oxidized form (TMBox) in the absence of HO.

Diabetes mellitus predicts inferior survival in diffuse large B-cell lymphoma: a propensity score-matched analysis.

Diabetes mellitus (DM) is associated with elevated cancer risk and poor survival. The objective of this study was to assess the prognostic value of DM in diffuse large B-cell lymphoma (DLBCL). Five hundred and fifty-three newly diagnosed DLBCL patients whose treatments included rituximab were recruited.

Corrosion Behavior of GH4169 Alloy under Alternating Oxidation at 900 °C and Solution Immersion.

In this paper, the corrosion behavior of GH4169 superalloy under alternating oxidation (at 900 °C) and solution immersion (in 3.5% NaCl solution, 30 ± 1 °C) has been studied by SEM, XRD, XPS, and electron probe microanalysis (EPMA). The results show that the alternating environment increases the corrosion rate of GH4169.

Toll-like receptor 3 acts as a suppressor gene in breast cancer initiation and progression: a two-stage association study and functional investigation.

Toll-like receptor 3 (TLR3) is a receptor recognizing double-stranded RNA (dsRNA) from viruses as well as from lytic mammalian cells. In the present study, we performed a two-stage association study (n = 3,551) and found that the minor alleles of two SNPs (the T-allele of rs5743312 and the T-allele of rs3775296) conferred increased risks of breast cancer incidence. The adjusted odds ratios (ORs) were 2.

Paris saponin VII extracted from trillium tschonoskii suppresses proliferation and induces apoptosis of human colorectal cancer cells.

Ethnopharmacological Relevance: Saponins of many herbs could inhibit the growth of colorectal cancer cells. In the study, we investigated the effects of Paris saponin Ⅶ (PSⅦ), and elucidated its mechanism in colorectal carcinoma cells and a xenograft mouse model.

Materials And Methods: HT-29 and HCT-116 cells were treated with different concentrations of PSⅦ (0-100 μM).

Author Correction: Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice.

The pathogenesis of Alzheimer's disease (AD) is characterized by both accumulation of β-amyloid (Aβ) plaque and formation of neurofibrillary tangles in the brain. Recent evidence shows that autophagy activation may potently promote intracellular Aβ clearance. Thus targeting autophagy becomes a promising strategy for discovery of drug leads against AD.

[Clinical Analysis of 37 Patients with Primary Tonsil Diffuse Large B Cell Lymphoma].

Objective: To investigate the clinical manifestation, immunophenotypes and prognostic factors of patients with primary tonsil afftive large B cell lymphoma ( PT-DLBCL ).

Methods: The clinical data including clinical characterstics, typing, staging, treatment efficacy and prognostic factors of PT-DLBCL patients were collected and analyzed restrospectively.

Results: Out of 36 cases with the detinite cell origin, 24 cases (66.

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma.

Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non-Hodgkin lymphoma with poor outcomes, remains to be determined. Therefore, we investigated the prognostic role of RDW in MCL.

Low absolute NK cell counts in peripheral blood are associated with inferior survival in patients with mantle cell lymphoma.

Background: Although risk stratification of mantle cell lymphoma (MCL) is most frequently performed using the simplified MCL International Prognostic Index (sMIPI), the identification of host-related factors and tumor microenvironment, including absolute monocyte counts (AMC) and peripheral blood T lymphocyte subsets, especially absolute natural killer cell counts (ANKC) has been suggested to be critical in the prediction of prognosis and the guidance of treatment.

Objective: This study was aimed at investigating whether peripheral blood ANKC and AMC at diagnosis had an impact on MCL prognosis.

Methods: A total of 92 newly diagnosed MCL patients was enrolled in this retrospective study.

Prognostic Value of Baseline and Interim Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT in Patients with Follicular Lymphoma.

Purpose: The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans.

Methods: The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2.

MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.

Activated KRAS is frequently observed and paralleled by inactivating of tumor suppressors in lung cancer, while the mechanisms remained elusive. Here, our study revealed a microRNA was involved in KRAS overexpression, activation of KRAS signaling and its synergy with inactivating of tumor suppressor genes. miR-1205 was selected by its sequence-dependent inhibition on KRAS and negative clinical correlation with KRAS.

Herbacetin treatment remitted LPS induced inhibition of osteoblast differentiation through blocking AKT/NF-κB signaling pathway.

Inflammation, a common situation during the process of bone healing, is reported to play a negative role in bone regeneration. Up to date, therapeutic strategies for inflammation triggered inhibition of osteoblast differentiation are still limited. The aim of this study was to explore the potential roles and molecular mechanisms of Herbacetin in the process of osteoblast differentiation under LPS-mediated inflammatory environment.

Pathogenic Gene Mutations or Variants Identified by Targeted Gene Sequencing in Adults With Hemophagocytic Lymphohistiocytosis.

Hemophagocytic lymphohistiocytosis (HLH) can be classified into primary HLH and secondary HLH. Primary HLH usually occurs in infants and children with an underlying genetic defect, and there are also teens and occasional adults with primary HLH. Most cases with secondary HLH are adult patients with secondary triggers including infections, malignancies, and autoimmune diseases.

Concurrent neoadjuvant chemotherapy and estrogen deprivation in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer (CBCSG-036): A randomized, controlled, multicenter trial.

Background: The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

Methods: Eligible patients with AJCC stage IIB to stage IIIC, ER-positive, HER2-negative breast cancer were enrolled and randomly assigned to receive NCT with or without estrogen deprivation. The primary endpoint was the objective response rate (ORR).

Sn-encapsulated N-doped porous carbon fibers for enhancing lithium-ion battery performance.

Tin (Sn) has wide prospects in applications as an anode electrode material for Li-ion batteries, due to its high theoretical specific capacity. However, the large volume expansion of Sn during the charge-discharge process causes a performance reduction of lithium-ion batteries (LIBs). Here, Sn encapsulated N-doped porous carbon fibers (Sn/NPCFs) were synthesized through an electrospinning method with a pyrolysis process.

Inhibition of astrocytic differentiation of transplanted neural stem cells by chondroitin sulfate methacrylate hydrogels for the repair of injured spinal cord.

Neural stem cell (NSC) transplantation exerts a therapeutic effect on spinal cord injury (SCI) but is limited to an unregulated differentiation pattern by which NSCs preferentially differentiate into astrocytes, with relatively few neurons. It is well established that the increased NSC-derived astrocytes exhibit aberrant axonal sprouting associated with allodynia-like symptoms of the forepaws. Some strategies have been used to overcome this issue, such as regulation of major pathways, ex vivo gene transfer, and genetic overexpression.

The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia.

Compromised placentation strongly predisposes to preeclampsia (PE) which is a severe complication of pregnancy. Pregnancy-associated plasma protein-A2 (PAPP-A2) has higher expression in the placenta than in any other tissues. However, the possible role of PAPP-A2 in placental development and in the pathogenesis of PE remains unclear.

Combination Therapies and Drug Delivery Platforms in Combating Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer-related death in the United States, is highly aggressive and resistant to both chemo- and radiotherapy. It remains one of the most difficult-to-treat cancers, not only due to its unique pathobiological features such as stroma-rich desmoplastic tumors surrounded by hypovascular and hypoperfused vessels limiting the transport of therapeutic agents, but also due to problematic early detection, which renders most treatment options largely ineffective, resulting in extensive metastasis. To elevate therapeutic effectiveness of treatments and overt their toxicity, significant enthusiasm was generated to exploit new strategies for combating PDAC.

Microstructure and Tribological Properties of Lamellar Liquid Crystals Formed by Ionic Liquids as Cosurfactants.

Lamellar liquid crystals (LLCs) have been shown to have lubrication properties in many documents due to their bilayer structure. Ionic liquids are often used as additive or surfactant in LLCs. However, ionic liquids used as cosurfactants, which lead to a transition from the hexagonal liquid crystals to LLCs, are relatively rare.