Publications by authors named "Lei Fan"

Objective: Neoadjuvant immunochemotherapy has been a promising choice for patients with locally advanced non-small cell cancer (NSCLC). However, whether neoadjuvant immunochemotherapy impacted the subsequent surgical or pathological outcomes of patients with pulmonary lymphoepithelioma-like carcinoma (PLELC) remains relatively unknown. This study aimed to evaluate the safety and efficacy of neoadjuvant immunochemotherapy in PLELC patients.

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Angioimmunoblastic T-cell lymphoma (AITL) is a kind of aggressive T-cell lymphoma with significant enrichment of non-malignant tumor microenvironment (TME) cells. However, the complexity of TME in AITL progression is poorly understood. We performed single-cell RNA-Seq (scRNA-seq) and imaging mass cytometry (IMC) analysis to compare the cellular composition and spatial architecture between relapsed/refractory AITL (RR-AITL) and newly diagnosed AITL (ND-AITL).

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The accurate monitoring of atmospheric water vapor is important for disaster prevention and environmental management. The ground-based BeiDou Navigation Satellite System (BDS) technique for atmospheric water vapor monitoring has demonstrated high accuracy and stable performance. Considering autonomy and safety, the standalone BDS receiver will be promoted in China and its surrounding areas for meteorological applications.

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Importance: Preferred neoadjuvant strategies for early or locally advanced triple-negative breast cancer include a 4-drug chemotherapy regimen containing anthracyclines, cyclophosphamide, taxanes, and platinum. Blockade of the programmed death receptor 1/ligand-1 (PD-1/PD-L1) pathway may improve efficacy of classic neoadjuvant chemotherapy. Camrelizumab, an anti-PD-1 antibody, has showed antitumor activity in advanced triple-negative breast cancer.

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Background: Extranodal natural killer/T-cell lymphoma (ENKTCL) is almost always fatal after the failure of asparaginase. This phase II study aimed to investigate the efficacy and safety of tislelizumab combined with gemcitabine and oxaliplatin (Tisle-GemOx) in patients with ENKTCL failing asparaginase.

Methods: Eligible patients received Tisle-GemOx as initial induction for 6-8 cycles at 21-day intervals.

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Article Synopsis
  • Astrocytes, which have a spongy structure and play a role in cognitive processes, show changes in their morphology related to learning and cognitive impairments, with a focus on the protein Ezrin.
  • Increased Ezrin expression and astrocyte fine process volume were found in the hippocampus of male mice after learning, while both declined with factors like lipopolysaccharide injection or cognitive dysfunction.
  • Knocking out Ezrin in astrocytes led to reduced fine process volume and worsened cognitive functions, indicating that Ezrin helps maintain astrocyte-synapse interactions essential for proper cognitive function.
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This study aimed to investigate the role of ubiquitin-specific peptidase 15 (USP15) in ischemic cognitive dysfunction using a mouse model and a cerebral ischemia (CI) cell model, its impact on ferroptosis and the underlying mechanisms. Oxygen-glucose deprivation/reoxygenation (OGD/ R)-induced HT-22 cells were used to establish the CI cell model, and mice induced with CI were used as the animal model for ischemic cognitive dysfunction. Cell damage was evaluated using Cell Counting Kit-8 (CCK-8), flow cytometry (FCM), immunoblotting, and immunofluorescence assays.

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Article Synopsis
  • * Participants included female patients aged 18-70 who had undergone surgery for early-stage triple negative breast cancer, with high-risk patients receiving a more intensive treatment regimen compared to standard therapy.
  • * Results showed that after a median follow-up of 45.1 months, the three-year disease-free survival rate was significantly higher for the intensive treatment group (90.9%) than for the standard treatment group (80.6%), indicating the potential benefits of personalized therapy based on
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Synopsis of recent research by authors named "Lei Fan"

  • - Lei Fan's recent research spans multiple disciplines, including infectious disease psychology, immunology, oncology, and artificial intelligence, showcasing a broad interest in both biological functions and the societal impacts of health crises, especially during the COVID-19 pandemic.
  • - Key findings include the lack of increased xenophobia linked to infectious diseases, the development of immune-modulating therapies using cow placenta extract, and the introduction of a prognostic computational framework for melanoma based on tumor mutational burden, highlighting innovative approaches to treatment and diagnostics.
  • - Fan’s work also emphasizes technological advancements, such as a physics-informed neural network for cardiac function assessment and a semantic segmentation framework for high-resolution remote sensing imagery, addressing complex challenges in medical modeling and environmental analysis.