IEEE Trans Neural Netw Learn Syst
February 2025
In this article, we attempt to study a problem of identifying outliers from multiple dimensions, terming it as multidimensional anomaly detection. This task assumes that each sample corresponds to heterogeneous discriminative spaces, where each space characterizes distinct semantic information along one dimension. Consequently, the abnormalities exhibited by a sample will vary under these semantically different dimensions.
View Article and Find Full Text PDFMCL1 is an anti-apoptotic member of the BCL2 protein family, and its overexpression is associated with poor prognosis across various cancers. Small molecule inhibitors targeting MCL1 are currently in clinical trials for TNBC and other malignancies. However, one major challenge in the clinical application of MCL1 inhibitors is the inherent or acquired resistance to these drugs.
View Article and Find Full Text PDFMultidrug-resistant Acinetobacter baumannii has emerged as one of the most antibiotic-resistant bacterial pathogens associated with nosocomial infection, with its resistance highly depending on multiple multidrug efflux pumps. Here, we report the cryoelectron microscopy (cryo-EM) structure of Acinetobacter drug efflux G (AdeG), the inner membrane component of one of three important resistance-nodulation-cell division (RND) pump family members in A. baumannii, which is involved in drug resistance to chloramphenicol, trimethoprim, ciprofloxacin, and clindamycin.
View Article and Find Full Text PDFThe third species of the small and rare stag beetle genus Capreolucanus Didier, 1928 was found from Yunnan Province, China: C. yanxui Qi & Zhou, new species. The complete mitogenome of the new species is assembled.
View Article and Find Full Text PDFBackground: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.
Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.
Front Cell Dev Biol
November 2024
S-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM). The zDHHC family, as an important member of S-palmitoyltransferases, has received extensive attention for its function and mechanism in GBM which is one of the most common primary malignant tumors of the brain and has an adverse prognosis.
View Article and Find Full Text PDFPredicting drug-target interaction (DTI) is of great importance for drug discovery and development. With the rapid development of biological and chemical technologies, computational methods for DTI prediction are becoming a promising approach. However, there are few solutions to the cold-start problem in DTI prediction scenarios, as these methods rely on existing interaction information to support their modeling.
View Article and Find Full Text PDFAiming to optimize straw resource utilization and to reduce air pollutant and greenhouse gas emissions in China, the environmental benefits of biochar production using straw and utilization need to be assessed. Two biochar production scenarios were studied: centralized production scenario (CPS) utilizing an industrialized production method with advanced air pollution control devices, and decentralized production scenario (DPS) based on a distributed production method of biochar at the village level, compared to an open-burning scenario (OBS). The potential GHG emission reductions under DPS, including the benefit of soil biochar application, were evaluated as 680 Tg CO-eq yr, which was lower than the reductions under CPS (780 Tg CO-eq yr).
View Article and Find Full Text PDFNatural indole alkaloids provide important medicinal resources and defences to environmental stresses. The Uncaria genus is a recorded traditional medicinal woody plant with high alkaloids. Genomic insights into alkaloid variation remain elusive.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is a leading cause of morbidity and mortality, and timely diagnosis and intervention are crucial for cancer patients. Transfer RNA-derived fragments (tRFs) play a noncoding regulatory role in organisms. Serum EV(extracellular vesicles), as an integral mediator of intercellular transmission of genetic information vesicles in Transfer RNA-derived fragment (tRF RNA), are expected to be minimally invasive diagnostic and predictive biologic factors of CRC.
View Article and Find Full Text PDFRiparian zones play a crucial role in reducing nitrate pollution in both terrestrial and aquatic environments. Complex deposition action and dynamic hydrological processes will change the grain size distribution of riparian sediments, affect the residence time of substances, and have a cascade effect on the biogeochemical process of nitrate nitrogen (NO-N). However, simultaneous studies on NO-N transformation and the potential drivers in riparian zones are still lacking, especially neglecting the effect of sediment grain size (SGS).
View Article and Find Full Text PDFThe ability to generate multiple RNA transcript isoforms from the same gene is a general phenomenon in eukaryotes. However, the complexity and diversity of alternative isoforms in natural populations remain largely unexplored. Using a newly developed full-length transcript enrichment protocol with 5' CAP selection, we sequenced full-length RNA transcripts of 48 individuals from outbred populations and subspecies of , and from the closely related sister species and as outgroups.
View Article and Find Full Text PDFIEEE Trans Nanobioscience
October 2024
Circular RNAs (circRNAs) play a crucial role in gene regulation and association with diseases because of their unique closed continuous loop structure, which is more stable and conserved than ordinary linear RNAs. As fundamental work to clarify their functions, a large number of computational approaches for identifying circRNA formation have been proposed. However, these methods fail to fully utilize the important characteristics of back-splicing events, i.
View Article and Find Full Text PDFSci Total Environ
November 2024
Wetlands are widely recognized as hot spots for the emission or deposition of biogenic sulfur gases, including hydrogen sulfur (HS) and sulfur dioxide (SO), which significantly affect air quality and climate change. With the expansion of urban wetlands, it is critical to know the roles that urban wetlands played in atmospheric HS and SO budget. In this study, the surface-air exchange fluxes of HS and SO were measured by the Dynamic Flux Chamber (DFC) method in a typical urban wetland in eastern China from Sep 2022 to July 2023.
View Article and Find Full Text PDFEnviron Sci Technol
September 2024
Direct nitrous oxide (NO) emissions from fertilizer application are the largest anthropogenic source of global NO, but the factors influencing these emissions remain debated. Here, we compile 1134 observations of fertilizer-induced NO emission factor (EF) from 229 publications, covering various regions and crops globally. We then employ an interpretable machine learning model to investigate the driving factors of fertilizer-induced NO emissions.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) is a major infectious disease with significant public health implications. Its widespread transmission, prolonged treatment duration, notable side effects, and high mortality rate pose severe challenges. This study examines the epidemiological characteristics of TB globally and across major regions, providing a scientific basis for enhancing TB prevention and control measures worldwide.
View Article and Find Full Text PDFUnderstanding the emission characteristics of particulate matter and associated heavy metals is essential for assessing their environmental and health impacts post-emission, as well as for identifying potential control technologies for the sources. Here, a field test was conducted at two advanced smelting plants equipped with comprehensive air pollution control devices. The particles emitted from different stages of lead and zinc smelting exhibited bi-modal size distributions, with peaks observed in PM and PM, respectively.
View Article and Find Full Text PDFExpert Opin Ther Pat
September 2024
Introduction: Cyclin-dependent protein kinase 4/6 (CDK4/6) is a class of serine/threonine protein kinases that plays a key role in the regulation of the cell cycle. CDK4/6 is highly expressed in cancers such as breast cancer, melanoma, and non-small cell lung cancer (NSCLC). Currently, a variety of CDK4/6 inhibitors have been developed, aiming to develop effective inhibitors to solve CDK4/6 resistance and toxicity.
View Article and Find Full Text PDFA thorough comprehension of nitrogen biogeochemical processes in the vadose zone is crucial for the effective prevention and remediation of soil-groundwater system contamination. Despite the growing research on this subject, the full scope of nitrogen biogeochemical characterization in different geological environments remains poorly understood. This study addresses this knowledge gap by integrating geochemical, microbiological and numerical simulation approaches to gain a deeper insight into nitrogen biogeochemistry in agriculture.
View Article and Find Full Text PDFNucleic Acids Res
August 2024
The burgeoning crisis of antibiotic resistance has directed attention to bacteriophages as natural antibacterial agents capable of circumventing bacterial defenses. Central to this are the bacterial defense mechanisms, such as the BREX system, which utilizes the methyltransferase BrxX to protect against phage infection. This study presents the first in vitro characterization of BrxX from Escherichia coli, revealing its substrate-specific recognition and catalytic activity.
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