Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.

Background: Despite the significant prevalence of chronic obstructive pulmonary disease (COPD) in Southwest China, cognitive function among middle-aged and elderly individuals in this area surpasses the national average. This study aims to reveal the overall pulmonary ventilation function status of this population, and investigate whether pulmonary ventilation dysfunction is a risk factor for mild cognitive impairment (MCI) in this region, as suggested by previous researches.

Methods: Data were obtained from the 2019-2021 baseline survey of a natural population cohort study conducted in Southwest China.

Physiological traits, gene expression responses, and proteomics of rice varieties varying in heat stress tolerance at the flowering stage.

Introduction/background: Global warming greatly limits the productivity of rice. Rice plants are highly sensitive to heat stress at the flowering stage. The selection of heat-tolerant varieties is considered the most effective approach for ensuring global food security in the coming decades.

Research into the Influence of Filtration Media Microstructure on Oil-Water Separation Performance.

Oil-water separation materials with specialized wettability have garnered significant attention in the field of oil-water separation due to the advantages of simple use and no secondary pollution. However, the adsorptive contamination of the filter surface by impurity phases and surfactants can cause a shift in the wettability of the filter surface. For efficient oil-water separation and improved resistance to adherent contamination on the oil-water separation membrane surface, herein, superwetted Cu nanofilms and smooth hydrophobic surfaces were prepared on SSM substrates by one-step electrodeposition and immersion methods, respectively.

Strategies and tools to construct stable and efficient artificial coculture systems as biosynthetic platforms for biomass conversion.

Inspired by the natural symbiotic relationships between diverse microbial members, researchers recently focused on modifying microbial chassis to create artificial coculture systems using synthetic biology tools. An increasing number of scientists are now exploring these systems as innovative biosynthetic platforms for biomass conversion. While significant advancements have been achieved, challenges remain in maintaining the stability and productivity of these systems.

Recognizing SARS-CoV-2 infection of nasopharyngeal tissue at the single-cell level by machine learning method.

SARS-CoV-2 has posed serious global health challenges not only because of the high degree of virus transmissibility but also due to its severe effects on the respiratory system, such as inducing changes in multiple organs through the ACE2 receptor. This virus makes changes to gene expression at the single-cell level and thus to cellular functions and immune responses in a variety of cell types. Previous studies have not been able to resolve these mechanisms fully, and so our study tries to bridge knowledge gaps about the cellular responses under conditions of infection.

A two-stage model for precise identification and Gleason grading of clinically significant prostate cancer: a hybrid approach.

Introduction: Accurate identification and grading of clinically significant prostate cancer (csPCa, Gleason Score ≥ 7) without invasive procedures remains a significant clinical challenge. This study aims to develop and evaluate a two-stage model designed for precise Gleason grading. The model initially uses radiomics-based multiparametric MRI to identify csPCa and then refines the Gleason grading by integrating clinical indicators and radiomics features.

Prediction of Lung Adenocarcinoma Driver Genes Through Protein-Protein Interaction Networks Utilizing GenePlexus.

Lung adenocarcinoma, a subtype of lung cancer, is produced by uncontrolled proliferation of somatic cells affected by some tumorigenic factors. The origin of this disease can be attributed to the concept of "cancer driver," which links the occurrence of tumor with specific changes in some key genes. These key genes can be identified at various molecular levels.

Longitudinal relationship between 24-Hour Movement behavior patterns and physical function and quality of life after stroke: a latent transition analysis.

Background: 24-hour movement behavior, including Physical activity (PA), Sedentary behavior (SB), and sleep, is independently associated with health after stroke. Few studies have explored 24-hour movement behavior patterns in stroke survivors and their transitions, as well as the health implications of the transitions. This study aimed to explore the different subgroups and stability of 24-hour movement behavior patterns in people after stroke and the relationship of profile transitions with physical function and health-related quality of life (HRQoL).

LAT4 drives temozolomide induced radiotherapy resistance in glioblastoma by enhancing mTOR pathway activation.

Background: Glioblastoma multiforme (GBM) represents the most prevalent form of primary malignant tumor within the central nervous system. The emergence of resistance to radiotherapy and chemotherapy represents a significant impediment to advancements in glioma treatment.

Methods: We established temozolomide (TMZ)-resistant GBM cell lines by chronically exposing U87MG cell lines to TMZ, and dimethyl sulfoxide (DMSO) was used as placebo control.

Danhong Injection Modulates Microglial Polarization and Neuroinflammation via the JUNB/NF-κB Pathway in Ischemic Stroke.

Ethnopharmacological Relevance: Ischemic stroke (IS) is a leading cause of death and disability in China. Danhong Injection (DHI) is a traditional Chinese medicine preparation made from Salvia miltiorrhiza var. miltiorrhiza and Carthamus tinctorius L.

Functionalized Bone Implant Inspired by Lattice Defense Strategy: Grid Management, Precise and Effective Multiple-Prevention of Osteomyelitis Recurrence and Promote Bone Regeneration.

Osteomyelitis with a high recurrence rate. Timely-prevention can avoid severe consequence and death. However, conventional drug response-release has the disadvantages of unnecessary release and waste, causing ineffective prevention.

Hyperbolic-Metamaterial-Based Optical Fiber SPR Sensor Enhanced by a Smart Hydrogel for Perspiration pH Measurements.

An optical fiber surface plasmon resonance (SPR) sensor, leveraging hyperbolic metamaterials (HMMs) and pH-sensitive hydrogels, has been devised for pH detection in perspiration. Dispersion-tunable HMMs enable the sensor to transcend the inherent structural constraints of an optical fiber and enhance its refractive index (RI) sensitivity. pH-sensitive hydrogels exhibit diverse swelling behaviors due to varying ionization degrees of carboxyl groups under different solution pH conditions, leading to a notable RI change.

Ubiquitin-Activating Enzyme E1 (UBA1) as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Insights into Immune Infiltration and Functional Implications.

Ubiquitin-Activating Enzyme E1 (UBA1), an E1 enzyme involved in the activation of ubiquitin enzymes, has been involved in the onset and progression of different cancers in humans. Nevertheless, the precise contribution of in breast cancer (BC) is still poorly characterized. In this study, a thorough investigation was carried out to elucidate the significance of UBA1 and validate its functionality in BC.

Low Melting Temperature Gallium-Indium Liquid Metal Anode for Solid-State Li-Ion Batteries.

Solid-state Li-ion batteries are attracting attention for their enhanced safety features, higher energy density, and broader operational temperature range compared to systems based on liquid electrolytes. However, current solid-state Li-ion batteries face performance challenges, such as suboptimal cycling and poor rate capabilities, often due to inadequate interfacial contact between the solid electrolyte and electrodes. To address this issue, we incorporated a gallium-indium (Ga-In) liquid metal as the anode in a solid-state Li-ion battery setup, employing LiPSCl as the solid electrolyte.

Global lncRNA expression signature in pre-metastatic lung and their regulatory effects in pulmonary metastasis.

Background: Lung metastasis has garnered significant attention due to its prevalent occurrence. Pre-metastatic niche (PMN) establishment is a critical prerequisite for the onset of lung metastasis. Emerging evidence indicates that long noncoding RNAs (lncRNAs) play pivotal roles in the metastatic cascade to the lungs.

Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios.

The increasing use of plastic food containers, particularly for pre-cooked meals and takeout services, has raised concerns regarding the potential health risks associated with plastic leachates. This study investigated the impact of leachates from heat-treated polypropylene (PP) plastic food containers on glucose and lipid metabolism using both in vitro and in vivo models. AML12 hepatocytes exposed to leachates from three different PP plastic containers exhibited significant disruptions in the homeostasis of lipid and glucose metabolism, evidenced by increased intracellular lipid content and altered gene expression related to lipogenesis, lipid uptake, lipolysis, and fatty acid β-oxidation.

Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis.

This study is to explore the effects of paeoniflorin (PF) on oxidative stress (OS) and inflammation in Parkinson's disease (PD) via the HSF1-NRF1 axis. SH-SY5Y cells were pretreated with PF and induced with α-synuclein preformed fibrils (PFF), followed by gain- and loss-of-function assays. Afterward, detection was conducted on cell viability, mitochondrial membrane potential ([Formula: see text]m), and reactive oxygen species (ROS), cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) levels.

Modulation of gel characteristics in surimi-curdlan gel system by different valence metal cations: Mechanical properties, ionic distribution and microstructure visualization.

The valence state of metal cations is a potential factor in regulating the structural properties of surimi gels. In this study, Surimi-Curdlan dual network (SCDN) gel was prepared by NaCl, KCl, CaCl and MgCl, combined with the concept of dual network hydrogel. The effects of different valence metal cations on mechanical properties, water state, microstructure, protein structure and composition of SCDN gel were studied.

Influence of Surface Wettability of Nonhomogeneous Proppant on Hydraulic Fracture Inflow Performance.

Quartz sand proppant is widely used in hydraulic fracturing and the extraction of low-permeability reservoirs to prevent fracture closure and enhance reservoir recovery effectively. The influence of proppant size and type on well productivity has been widely studied, but the mechanism of proppant surface wettability on the hydraulic fracture inflow performance has not been thoroughly investigated. To further understand the influence of proppant wettability on fracture inflow performance, in this work, a hydrophobic quartz sand proppant was prepared by a simple dip-coating method using silane solution with a static water contact angle of 136.

Trends in disease characteristics and premature mortality among hospitalised middle-aged patients in Anhui Southern Area, China, between 2011 and 2020: a cross-sectional study.

Objectives: We aimed to explore the characteristics of age, disease and premature mortality among middle-aged inpatients.

Design: Cross-sectional.

Setting: Data were gathered from the electronic medical records system of the hospitals between 2011 and 2020: a regional study.

Decomplexation of Pb-EDTA by electron beam irradiation technology: efficiency and mechanism.

As a common heavy metal complex in industrial wastewater, Pb-EDTA has garnered much attention due to its detrimental impact on both human health and the ecological environment. The degradation of heavy metal complexes by traditional methods requires subsequent treatment to recover heavy metals. This article attempts to find an effective method to simultaneously degrade both organic matter and heavy metal pollutants.

Integrated transcriptomic and metabolomic analyses reveal heterosis for meat quality of Neijiang pigs.

Obese pig breeds have excellent meat quality, while lean pig breeds have high lean meat percentage and feed conversion rate. However, due to their respective shortcomings, obese pig and lean pig breeds are unable to balance production and consumption needs. Therefore, this study crossbred the obese Chinese pig breed Neijiang (NJ) with lean type Large White pigs (LW) to produce Neijiang × Large White(NL) pigs.