[The pathogenetic aspects of diabetic involvement of the heart].

As many as 107 patients with diabetes mellitus were enrolled in the study. It has been found out that under diabetic metabolic disturbances there occur significant changes in structural-and-functional characteristics of proteins, including myocardial ones, believed to be of much importance to the pathogenesis of diabetic affection of the heart and to the functional state of the myocardium.

[Late ventricular potentials, ventricular arrhythmias and sudden death in patients with acquired heart defects].

Late ventricular potentials (LVP) were registered in patients with acquired valvular disease and compared to the data obtained at 24-h ECG monitoring, echocardiography and prospective 1.5-2-year follow-up. LVP were found in 14.

[The characteristics of the psychological status of myocardial infarct patients and geomagnetic factors].

An analysis is presented of myocardial infarction (MI) incidence during a 366-day period. Results were compared with prognostic and real unfavourable days by geomagnetic values (data of the Geophysical Institute in Göttingen (Germany)). There was no essential morbidity rise in the unfavourable days but a greater number of IM was noted during coincidence of prognostic and real unfavourable days.

[The metabolic characteristics of the blood leukocytes in infectious-allergic myocarditis and dilated cardiomyopathy].

41 patients with dilated cardiomyopathy (DCMP), 62 patients with infectious allergic myocarditis (IAMC) and 36 patients with myocarditis cardiosclerosis (MCCS) were examined cytochemically. This involved assessment of the activity of alpha-glycerophosphate- and glucose 6-phosphate dehydrogenases, nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate diaphorases, NBT test parameters, measurements of endogenic cytochrome C and cation protein, activity of acid and alkaline phosphatase, lymphocyte peroxidase and that in peripheral blood polymorphonuclear leukocytes. The findings of the study confirmed a close functional and metabolic relation of the above cytochemical indices.

[Echocardiographic assessment of cardiac pump function using afterloading characteristics].

Seventy five patients and twenty healthy individuals were investigated by using cardiac ultrasound technique, followed by mathematical simulation of changes in left ventricular pressure during contraction. The findings show that the afterload characteristics based on a wealth of evidence for cardiac and left ventricular performance, unlike the conventional central hemodynamic parameters and cardiac phasic indices, enable the occult circulatory disorders to be revealed and the cardiac compliance with the arterial system to be assessed.

[Treatment of refractory arterial hypertension by plasmapheresis].

58 patients with severe arterial hypertension (AH) refractory to antihypertensive drug therapy including beta-blockers, calcium antagonists, antiadrenergic drugs and diuretics with addition of captopril and/or minoxidil were studied. In all the patients 3-6 sessions of plasmapheresis (PA) with plasma exchange up to 30 ml/kg body weight per 1 session were performed. After the course of plasmapheresis BP depression on the average by 24% as well as restoration of sensitivity to antihypertensive drugs and elimination of signs of malignant AH in certain cases were observed.

[The renin-angiotensin-aldosterone system and antidiuretic hormone secretion during plasmapheresis in patients with high arterial hypertension refractory to drug therapy].

Plasmapheresis (PP) was used in 28 patients with medication-resistant high arterial hypertension (AH). PP-induced changes in plasma renin activity and blood aldosterone, angiotensin II and antidiuretic hormone levels of patients with high AH are shown to be a compensatory-adaptive response, maintaining homeostasis. PP sessions (27 ml/kg body weight at a rate of 0.

Extracorporeal methods in the management of severe and malignant arterial hypertension.

Novel approaches to managing refractory arterial hypertension (AH) have been tested in 130 patients aged 28 to 59 years with severe or malignant hypertension. Hemosorption was performed in 70 patients in whom AH was caused by chronic diffuse glomerulonephritis (49 cases) or chronic pyelonephritis (21 cases) accompanied by the appearance of chronic renal failure. In all patients, blood pressure after hemosorption decreased by 15% to 16% on the average, resulting in progressively improved renal function and a nearly 2.

[Use of plasmapheresis in the treatment of patients with severe arterial hypertension refractory to drug therapy].

Thirty patients with severe and malignant arterial hypertension (AH) received 1-4 sessions (in most cases 2) of plasmapheresis to overcome refractiveness to drug therapy. Stable BP reduction, improvement of the vascular picture of the fundus of the eye and raised sensitivity to antihypertensive therapy were noted in 26 patients. Though antihypertensive drug dosages were reduced, the antihypertensive effect of plasmapheresis could be observed within 3-8 mos (an average of 5.

[Clinical and hemodynamic evaluation of the effectiveness of plasmapheresis in high arterial hypertension refractory to drug treatment agents].

Indices of central hemodynamics based on tetrapolar rheography results with subsequent calculation of left ventricular post-load characteristics were studied in parallel with the assessment of clinical efficacy of plasmapheresis in 36 patients with therapy-resistant severe arterial hypertension. Plasmapheresis in severe arterial hypertension resulted not only in BP reduction and overcoming of refractoriness to medical therapy but also produced a beneficial effect on the cardiovascular system improving left ventricular post-load characteristics.

[Hypotensive effect of plasmapheresis in patients with severe symptomatic arterial hypertension of renal origin].

The article presents the results of using plasmapheresis in 8 patients with high arterial hypertension refractory to drug therapy. After 2 plasmapheresis procedures a stable BP decrease was observed in all patients allowing a further decrease of hypotensive drug administration. The hypotensive effect of plasmapheresis was accompanied by an improvement of the eye fundus and of renal function, decreased proteinuria and increased sensitivity to hypotensive therapy.

[Clinico-immunological assessment of the effectiveness of plasmapheresis in the combined therapy of patients with high arterial hypertension].

After several plasmapheresis procedures 25 out of 28 patients with high arterial hypertension revealed stable BP lowering, accompanied by elimination of their refractoriness to medical therapy. Enhanced sensitivity of lymphocytes to antihypertensive drugs has been established by lymphocyte rosette-formation with allogenic erythrocytes loaded with these preparations. Plasmapheresis was followed by moderate reduction in IgA, IgM and IgG levels with their subsequent recovery to baseline values within 3-7 days.