Publications by authors named "Lefrere A"
Background: Quality of life is decreased in bipolar disorders (BD) and contributes to poor prognosis. However, little is known about the causal pathways that may affect it. This study aimed to explore health-related QoL (HRQoL) in BD and investigate its relationship with cognition and psychosocial functioning.
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- Bipolar disorder (BD) is a complex mental health condition, and researchers aimed to identify a neurodevelopmental phenotype (NDP) that contributes to its development and impacts clinical outcomes.
- By analyzing data from over 4,400 BD patients, they established nine specific clinical features that characterize this NDP, which are linked to poorer prognosis and treatment responses.
- The findings suggest that patients with a higher NDP load may have overlapping genetic factors with ADHD, indicating a potential shared biological basis for these disorders.
Background: Nutrition is largely affected in bipolar disorder (BD), however, there is a lack of understanding on the relationship between dietary categories, BD, and the prevalence of metabolic syndrome. The objective of this study is to examine dietary trends in BD and it is hypothesized that diets with increased consumption of seafood and high-fiber carbohydrates will be correlated to improved patient outcomes, and a lower frequency of metabolic syndrome.
Methods: This retrospective cohort study includes two French cohorts.
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- Individuals with bipolar disorders (BD) tend to have a shorter life expectancy, prompting the need for easily measurable markers of accelerated aging like BioAge, calculated from routine blood tests and physical exams.
- In a study of 2,220 outpatients with BD, results showed that a small percentage had significant BioAge Acceleration, which is linked to factors such as young age, male sex, being overweight, and sleep issues.
- Further research is needed to confirm these findings with different groups and explore whether improving factors like metabolic health and sleep could impact aging rates in individuals with BD.
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- This study investigates the link between mitochondrial blood biomarkers, specifically lactate and circulating cell-free mitochondrial DNA, and markers of metabolic syndrome in bipolar disorder patients, hypothesizing that lactate levels would be higher in those with metabolic syndrome.
- The research involved a large cohort of 837 stable bipolar disorder patients and 237 others for validation, revealing that higher lactate levels correlated significantly with factors like triglycerides and blood pressure, indicating a strong association with metabolic syndrome.
- The findings suggest that while lactate is a key biomarker related to metabolic syndrome in bipolar patients, circulating mitochondrial DNA levels do not show this same correlation, highlighting the potential for personalized treatment strategies based on these metabolite profiles.
Monitoring of lamotrigine levels is recommended in epilepsy. However, in bipolar disorders (BD), no study has described the therapeutic range in daily practice and factors being associated to it. We used retrospective data of individuals with BD, treated with lamotrigine, and included in the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort.
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- Bipolar disorder is linked to premature cellular aging, evidenced by shortened telomere length (TL), particularly in a subgroup of young individuals.
- A study analyzed 542 individuals with bipolar disorder, finding a cluster of young people (average age 29.64) with significantly shorter TL.
- Gene expression analysis revealed decreased levels of the gene POT1 in this subgroup, indicating a potential new mechanism related to telomere shortening in bipolar disorder.
Introduction: The purpose of this update is to add newly approved nomenclatures and treatments as well as treatments yet to be approved in major depressive disorder, thus expanding the discussions on the integration of resistance factors into the clinical approach.
Methods: Unlike the first consensus guidelines based on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology (AFPBN) developed an update of these guidelines for the management of partially responsive depression (PRD) and treatment-resistant depression (TRD). The expert guidelines combine scientific evidence and expert clinicians' opinions to produce recommendations for PRD and TRD.
Introduction: Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%.
View Article and Find Full Text PDFBipolar disorders (BD) are characterized by cognitive impairment during the euthymic phase, to which treatments can contribute. The anticholinergic properties of medications, i.e.
View Article and Find Full Text PDFBackground: Converging evidence suggests that a subgroup of bipolar disorder (BD) with an early age at onset (AAO) may develop from aberrant neurodevelopment. However, the definition of early AAO remains unprecise. We thus tested which age cut-off for early AAO best corresponds to distinguishable neurodevelopmental pathways.
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- Analyzing cortical folding may help understand the biological factors behind neurodevelopmental diseases, specifically focusing on a subtype of bipolar disorders known as BD-ND characterized by early onset and psychotic features.
- The study involved MRI scans of 512 participants, comparing the number and depth of sulcal pits – the deepest points in brain folds – across different groups, including BD-ND, a non-neurodevelopmental bipolar group, and healthy controls.
- The results indicated that the BD-ND group had more sulcal pits overall, particularly in the left premotor cortex, suggesting distinct brain morphology that could provide insights into neurodevelopment in mood disorders and aid in patient classification.
If there is an abundant literature on the impact of bipolar illness on the family and/or caregivers of patients, few studies have addressed its impact on marital relationship and couple functioning. Uncovering information relating specifically to this topic may be particularly relevant due to the unusually high divorce rate among individuals with bipolar disorder. We therefore conducted a systematic literature search to evaluate the existing data on bipolar disorder and marital issues, with a special focus on the help and support that can be provided by mental health professionals in this regard.
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