Transition of care in stroke patients discharged home: a single-center prospective cohort study.

Introduction: Approximately two-thirds of the patients admitted to the hospital with an ischemic stroke are discharged directly home. Discontinuity of care may result in avoidable patient harm, re-admissions and even death. We hypothesized that the transfer of information is most essential in this patient group since any future care for these patients relies solely on the information that is available to the care provider responsible at that time.

Complementary global maps for orientation coding in upper and lower layers of the cat striate cortex and their possible functions.

Preferred stimulus orientations of striate cortical cells in the cat were analyzed for possible isotropic or anisotropic distributions. We separated the data twice, into central (0-5 degrees) vs. peripheral subgroups and into upper vs.

Effect of a low-molecular weight serine proteinase inhibitor (camostate) on amylase release from isolated pancreatic acini.

Oral administration of the proteinase inhibitor camostate to rats results in a characteristic regulation of pancreatic enzyme synthesis and release. These effects are thought to be mediated by an endogenous cholecystokinin release in answer to camostate feeding. An additional direct effect of the compound could be exerted directly on the acinar cell.

Some fundamental points concerning the clinical aspects of desensitization.

Continued exposure of target cells to a hormonal agonist frequently leads to a blunted response to that agonist. This process has been termed desensitization, refractoriness, tolerance or tachyphylaxis. The receptor involved in case of beta-sympathomimetics is the beta-adrenergic receptor.

Quantitative analysis of terbutaline by gas chromatography-mass spectrometry.

Over the past 6 years, several gas chromatography-mass spectrometry (GC-MS) methods for terbutaline have been developed, each with certain advantages and disadvantages. They all involve monitoring of an ion selected from the mass spectrum of a suitable terbutaline derivative. This technique, often referred to as mass fragmentography or selected ion monitoring, reduces the interference from other drugs and endogenous compounds.

Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol.

The protective effects of oxyphenonium bromide, terbutaline and theophylline were compared in 8 asthmatic patients by determination of the degree of non-specific airway reactivity after 1 week of oral treatment according to a fixed dose scheme in a double-blind random order: oxyphenonium bromide 3 X 10 mg; terbutaline 3 X 5 mg; theophylline 2 X 300 mg and placebo. Controlled, standardized inhalation provocation tests were carried out with histamine, acetylcholine and propranolol. The study was monitored by measuring blood concentrations of the 3 drugs, and their effect on the plasma cAMP concentration was also determined.

The effects of oral and subcutaneous administration of terbutaline in asthmatic patients.

In 8 asthmatic subjects, serum concentrations of terbutaline were correlated with changes in volume of air expelled in the first second of forced expiration (FEV1), other parameters of lung function, c-AMP plasma concentrations and finger tremor values after administration of either 5 mg terbutaline sulphate orally, 0.5 mg terbutaline sulphate subcutaneously or an oral placebo. Prior to the investigation, the patients had not used bronchodilators for 10-14 days.

Terbutaline serum concentrations related to different lung function parameters and beta-receptor function.

In eight asthmatic and six normal subjects serum terbutaline concentrations were correlated with changes in FEV1, MEF50%, Gaw, sGaw, and plasma cAMP concentrations after administration of 0.5 mg terbutaline subcutaneously, 5 mg orally, and an oral placebo. In asthmatics and normals the changes in serum terbutaline levels and plasma cAMP levels were closely correlated and in the same range.

Tremor measurement in asthma. II. Changes after terbutaline administration suggesting beta-adrenergic blockade.

Repeated finger tremor measurements have been performed in six normal and eight asthmatic subjects after subcutaneous and oral administration of terbutaline. Prior to the investigations the patients had not used bronchodilators for 10-14 days. The finger tremor pattern showed a striking parallelism with the terbutaline serum concentrations and with the cAMP plasma levels.

Pharmacokinetics of terbutaline, a beta 2-sympathomimetic, in healthy volunteers and asthmatic patients.

The pharmacokinetics of 1-(35-dihydroxyphenyl)-2-(tert.butylamino)ethanol (terbutaline, Bricanyl) after i.v.

Correlation between terbutaline serum levels, c-AMP plasma levels and FEV1 in normals and asthmatics after subcutaneous administration.

Terbutaline serum levels, c-AMP plasma levels and percentage improvement in FEV1, were strongly correlated after subcutaneous administration of terbutaline to normals (n = 6) and to asthmatics (n = 5). Changes in c-AMP plasma levels were similar in both normals and asthmatics after subcutaneous administration, denying a systemically beta-adrenergic defect to be present in asthmatics.

Pharmacokinetics of terbutaline after subcutaneous administration.

The pharmacokinetics of terbutaline has been studied after subcutaneous adminsitration of a therapeutic dose of 250 microgram in 14 patients. Short absorption half-lives of about 7 min resulted in a fast uptake of the drug. Serum concentrations of terbutaline were measured up to 10 hr after administration, depending on the individual.

STRIPACT, an interactive curve fit programme for pharmacokinetic analyses.

An interactive computer programme was written for a small computer to perform curve fitting in pharmacokinetic analyses. The programme can handle data with or without an absorption phase. It considers, however, the absorption process to be of first-order kinetics.

Determination of terbutaline in post mortem human tissues by gas chromatography-mass spectrometry.

A method is described for the quantitative analysis of terbutaline in human tissues. Gas chromatography and chemical ionization mass fragmentography are used for selective and sensitive detection. A detection limit of 1.

Electron impact and chemical ionization mass spectrometry of some butyrophenones.

The mass spectra of some butyrophenones are presented. Electron impact ionization and chemical ionization with isobutane as the reagent gas are compared. The chemical ionization spectra show the quasi molecular ion (M + H)+ to be the most abundant ion.

The analysis of terbutaline in plasma and urine at therapeutic levels using mass fragmentography.

A sensitive method for the qualitative and semiquantitative determination of terbutaline in plasma and urine has been developed. After a single oral dose of 5 mg terbutaline sulphate the drug could be analysed easily. The detection limit in plasma is less than 1 ng ml-1.