Publications by authors named "Leeroy Baron"
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis. Identifying where this chemistry takes place in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Whereas genetic approaches have revealed underlying mechanisms of lipid peroxide detoxification, small molecules can provide unparalleled spatiotemporal control of the chemistry at work.
View Article and Find Full Text PDFThis symposium is the 5th PSL (Paris Sciences & Lettres) Chemical Biology meeting (2015, 2016, 2019, 2023, 2024) held at Institut Curie. This initiative originally started at Institut de Chimie des Substances Naturelles (ICSN) in Gif-sur-Yvette, with a strong focus on chemistry. It was then continued at the Institut Curie (2015) covering a larger scope, before becoming the official PSL Chemical Biology meeting.
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- Inflammation is a vital immune response to harm but can become excessive, contributing to various diseases and is not completely understood at the molecular level.
- The glycoprotein CD44 helps cells take up metals like copper, which, when present in mitochondria of inflammatory macrophages, plays a crucial role in their metabolic and epigenetic changes.
- Targeting mitochondrial copper with the compound LCC-12 can reduce inflammation and alter macrophage behavior, suggesting a promising new therapeutic approach for managing inflammation and enhancing immune responses.
This symposium is the third PSL (Paris Sciences & Lettres) Chemical Biology meeting (2016, 2019, 2023) held at Institut Curie. This initiative originally started at Institut de Chimie des Substances Naturelles (ICSN) in Gif-sur-Yvette (2013, 2014), under the directorship of Professor Max Malacria, with a strong focus on chemistry. It was then continued at the Institut Curie (2015) covering a larger scope, before becoming the official PSL Chemical Biology meeting.
View Article and Find Full Text PDF