Publications by authors named "Leena Rajith"

Article Synopsis
  • Advances in porphyrin chemistry led to the creation of a TCPP-ZnCoO composite for use in a novel optical sensor targeting uric acid detection.
  • The synthesis involved a simple one-pot hydrothermal method, and the composite's characteristics were analyzed using various spectroscopic techniques.
  • The developed sensor demonstrated high sensitivity, with a detection limit of 0.015 nM, effectively quantifying uric acid in human urine samples.
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5,10,15,20-tetramethoxyphenylporphyrinatotin (IV) (SnTMPP) was synthesised. SnTMPP exhibited Soret band at 432 nm and emission peaks at 629 and 682 nm. The fluorescence intensity of SnTMPP was quenched in the presence of guanine linearly in the range 4 × 10 M to 7.

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Porphyrins absorb strongly in the visible region and are also excellent fluorophores that emit in the visible region that make them excellent candidates for fluorescence sensing and in vivo imaging. This work describes the fluorescence determination of adenine using cobalt complex of a simple porphyrin. Tetraphenylporphyrin (TPP) and tetraphenylpophyrinatocobalt(II) (CoTPP) were synthesized and characterised.

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Porphyrins are highly conjugated molecules that perform wide variety of functions in biological systems. They absorb strongly in the visible region and they are excellent fluorophores that emit in the visible region. If the meso or β positions of porphyrins are properly substituted, emission in the NIR region is facilitated.

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The electro reductive behavior and determination of bromate on [5, 10, 15, 20-tetrakis (4-methoxyphenylporphyrinato] Manganese (III) chloride (TMOPPMn(III)Cl) modified Gold electrode(GE) was investigated by Square wave voltammetry (SWV). Bromate showed an irreversible reduction peak at -164 mV in 0.1 M pH 7 Na2SO4 solution.

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Fluorescent PET (Photoinduced Electron Transfer) has been of particular growth in recent times. A novel PET based fluorescent sensor using unmodified CdSe quantum dots (QDs) has been developed for the trace determination of Nimesulide (NIM). The sensor is based on the selective fluorescence quenching of quantum dots by NIM in presence of other NSAIDs and is found that intensity of quenching is linearly related to NIM concentration in the range 8.

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Trimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis.

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