Publications by authors named "Leena M Abdelrahman"
Gastroenterology
May 2024
Article Synopsis
- This study explores how regulatory T cells (Tregs) behave in inflammatory bowel diseases like Crohn's disease, focusing on their metabolic processes that impact gut homeostasis.
- Researchers used various advanced techniques (like electron microscopy and mass cytometry) to analyze Tregs' cellular structures and functions in humans and murine models of colitis.
- Key findings show that inhibiting a specific protein (VDAC1) disrupts Treg metabolism and increases sensitivity to inflammation, while manipulating metabolic pathways can restore proper Treg function and potentially inform new therapeutic strategies for inflammatory diseases.
