Publications by authors named "Leena Grace B"
Article Synopsis
- Breast cancer is a major health issue for women globally, and this study aimed to explore the link between BRCA1 promoter methylation and specific genetic variants (rs11655505) and gene expression in sporadic breast cancer cases.
- The research utilized tissue samples from 29 breast cancer patients and 26 healthy individuals, employing techniques to analyze DNA methylation and gene expression, particularly focusing on estrogen receptor statuses.
- Findings indicated no significant differences in methylation status or genetic variants between cancer and control groups; however, the heterozygous CT genotype showed reduced BRCA1 expression in tumor samples, suggesting a potential relationship between genetic variation and disease, particularly tied to methylation status in tumors.
Background: The human progesterone receptor (hPR) belongs to the steroid receptor family. It may be found as monomers (A and B) and or as a dimer (AB). hPR is regarded as the prognostic biomarker for breast cancer.
View Article and Find Full Text PDFWith increasing use of plant-based cancer chemotherapeutic agents, exploring the antiproliferative effects of phytochemicals has gained increasing momentum for anticancer drug design. The present study was undertaken to investigate the effect of root bark of Juglans regia (RBJR) organic extracts on cell proliferation, and to determine the molecular mechanism of RBJR-induced cell death by determining the expression of Bcl-2, Bax, caspases, Tp53, Mdm-2 and TNF-alpha in MDA-MB-231 human breast cancer cells. The results demonstrate that WNRB suppressed proliferation and induced apoptosis in a dose and time dependent manner by modulating expression of key genes.
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