Publications by authors named "Leena Ahad"
Article Synopsis
- Biomolecular condensates are membraneless cell compartments that form through liquid-liquid phase separation (LLPS), playing a crucial role in both normal cellular functions and cancer development.
- Recent research shows how these condensates influence the Hippo signaling pathway, which is vital for organ development and cancer progression, particularly impacting the YAP and TAZ proteins.
- The review emphasizes the potential of targeting these condensates in cancer treatment, as they can alter gene expression and promote tumor growth by changing how transcriptional co-activators and chromatin interact.
Bohring-Opitz syndrome (BOS) is a rare genetic condition caused by pathogenic variants in ASXL1, which is a gene involved in chromatin regulation. BOS is characterized by severe intellectual disabilities, distinctive facial features, hypertrichosis, facial nevus simplex, severe myopia, a typical posture in infancy, variable anomalies, and feeding issues. Wilms tumor has also been reported in two individuals.
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