Publications by authors named "Leena Abdalla"
Background: Anemia is a global public health concern, affecting both developing and industrialized countries at a rate of 39.8%. It is defined by low hemoglobin concentration, and anemia varies in severity based on age: <11 g/dL (6-59 months), <11.
View Article and Find Full Text PDFBackground: Chronic lymphocytic leukemia (CLL) is one of the hematological malignancies in which the bone marrow overproduces mature, dysfunctional lymphocytes. Affected lymphocytic cells can affect the lymph nodes, spleen, liver, bone marrow, and rarely other organs. Spontaneous rupture of the spleen is a rare health condition, with a few cases caused by CLL.
View Article and Find Full Text PDFBackground: Sickle cell disease (SCD) is a group of hereditary diseases, inherited as autosomal recessive disorder, which causes mutation in the β-globin gene. As a result, there is a change in the sixth amino acid from glutamic acid to valine. The affected red blood cell is then prone to polymerization and sickling crisis under conditions of low oxygen tension.
View Article and Find Full Text PDFArticle Synopsis
- Crohn's disease (CD) is a serious inflammatory condition of the digestive tract influenced by genetics, the immune system, and the environment; infliximab is a treatment option specifically for its fistulated form.
- A 63-year-old man diagnosed with CD developed a rare, non-immune drug-induced hemolysis after receiving infliximab, which was treated successfully with steroids and led to improvements in his hemoglobin levels.
- Interestingly, despite the potential for cross-reactions among biological treatments, switching the patient to adalimumab after the hemolysis did not result in any further complications or reactions.
Essential thrombocythemia is one of the famous diseases under the category of myeloproliferative disorder. It is an end result of a genetic mutation of one or more of the most frequent oncogenes such as Janos kinase 2 (JAK2), MPL proto-oncogene, thrombopoietin receptor (MPL), and calreticulin (CALR). However, negative genetic markers, so-called (triple negative disease), can happen in the presence of other uncommon types of mutation.
View Article and Find Full Text PDFUnlabelled: Chronic neutrophilic leukaemia is a very rare disease with diagnosis based on persistent leucocytosis >25×10/μl and monocytes <1×10/μl. The revised WHO criteria 2016 included CSF3R gene mutations as a diagnostic finding. We report the case of a 77-year-old man who was found to have asymptomatic persistent mature neutrophilic leucocytosis with monocytosis.
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was first discovered in December 2019 and turned to be pandemic in early March 2020. We aimed to describe the dominant ABO group and outcomes of critically ill patients (respiratory failure requiring mechanical ventilation and mortality) in a Saudi Arabian setting.
Methods: We conducted an observational, analytic cross-sectional, retrospective study in a tertiary care hospital.
Critical Care COVID-19 Patient with a Picture of Thrombotic Thrombocytopenic Purpura.
Eur J Case Rep Intern Med
December 2020
Article Synopsis
- Thrombotic thrombocytopenic purpura (TTP) can manifest in patients with COVID-19, displaying symptoms similar to the disease, as seen in a case of a 51-year-old man with severe COVID-19 and prior kidney transplant.
- The patient presented with the classic symptoms of TTP, including low platelet count and kidney injury, and improved significantly after five therapeutic plasma exchange sessions.
- This case underscores the urgency of managing TTP, highlights COVID-19's potential complications, particularly in immunocompromised patients, and suggests that further research is needed on therapeutic plasma exchange for severe COVID-19 cases.
Article Synopsis
- * A 17-year-old male exhibited symptoms including body aches and swelling on the right side of his head, along with rapid periorbital puffiness, which scans showed to be multiple subgaleal haematomas and edema.
- * Both conditions are uncommon in sickle cell disease but can be managed conservatively rather than through surgery, as demonstrated in the case of this patient.