Publications by authors named "Leeha Mahmood"
Article Synopsis
- A new physiologically based pharmacokinetic (PBPK) model for adeno-associated virus (AAV) therapy was created to improve drug development, based on studies in mice.
- The study examined the distribution of AAV8 and AAV9 vectors and their encoded monoclonal antibody (mAb) over three weeks, revealing tissue-to-blood concentration ratios that varied significantly across different organs.
- The developed PBPK model captures the pharmacokinetics of both the AAV vector and the mAb, highlighting liver, muscle, and heart as key contributors to mAb secretion, and it will aid in preclinical study design and the transition from animal studies to human trials.
