A review of the influence of pH on toxicity testing of acidic environmental chemical pollutants in aquatic systems using zebrafish (Danio rerio) and glyphosate toxicity as a case study.

Glyphosate is an acidic herbicide reported to contaminate water sources around the globe. Glyphosate alters the pH of a solution depending upon the concentration and buffering capacity of the solution in which it is present. Hence, toxicity observed in laboratory-based studies could be caused by the chemical or acidic pH if the solution is not adjusted to neutral conditions, confounding toxicity assessments.

Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.

Unlabelled: Atrazine (ATZ), the second most commonly used herbicide in the United States, is an endocrine disrupting chemical linked to cancer and a common drinking water contaminant. This study further investigates ATZ-related developmental toxicity by testing the following hypotheses in zebrafish: the effects of embryonic ATZ exposure are dependent on timing of exposure; embryonic ATZ exposure alters brain development and function; and embryonic ATZ exposure changes protein abundance in carcinogenesis-related pathways. After exposing embryos to 0, 0.