Publications by authors named "Lee-Bareket Kisler"
Article Synopsis
- The study investigates the role of the primary motor cortex (M1) in pain modulation using Transcranial Magnetic Stimulation (TMS) to create a virtual lesion (VL) and assess its impact on pain ratings during noxious heat stimuli.
- Three different timing protocols for TMS were applied to determine if interrupting M1 activity affects pain perception, compared against a control (SHAM-VL) and a pain-only condition.
- Results showed no significant differences in pain ratings across the conditions, suggesting that targeting M1 with a single pulse TMS-VL does not effectively disrupt pain processing in the contexts tested.
The primary motor cortex (M1) is a known target for brain stimulation aimed at pain alleviation in chronic pain patients, yet the mechanisms through which analgesia occurs, and the exact pain-motor interrelations are not fully understood. We used noxious contact heat evoked potentials (CHEPs) and cortical source analysis to further explore the relevance of M1 in pain processing. Twenty-four healthy young females received brief noxious heat stimuli to their left non-dominant volar forearm, simultaneously with CHEPs recordings.
View Article and Find Full Text PDFBehavioral studies found greater pain sensitivity in females that vanishes fully or partially when controlling for the emotional state. Furthermore, pain-related brain activation hints at the role of limbic structures in sex differences in pain processing. We aimed to investigate the role of pain-related limbic structures in mediating the relation between subjects' affective state (i.
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