Publications by authors named "Lee-Ang Lyu"
This study describes the creation and characterization of drug carriers prepared using the polymer poly[aniline-co-N-(1-one-butyric acid) aniline] (SPAnH) coated on Fe(3)O(4) cores to form three types of magnetic nanoparticles (MNPs); these particles were used to enhance the therapeutic capacity and improve the thermal stability of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a compound used to treat brain tumors. The average hydrodynamic diameter of the MNPs was 89.2 ± 8.
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- Malignant glioma is a severe brain tumor with a high risk of recurrence and mortality, even with treatment options like surgery and chemotherapy.
- The study combines focused ultrasound to temporarily open the blood-brain barrier and an external magnetic field to enhance the delivery of a chemotherapy drug using specialized magnetic nanoparticles.
- This method significantly improved drug delivery in rodent models, effectively suppressing tumor growth while sparing normal brain tissue, and allows for monitoring via MRI, offering a promising, less invasive treatment approach.
Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood-brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters.
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