Publications by authors named "Lee T Call"
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in downstream effector functions as inhibitors of apoptosis and as positive regulators of G1-S phase progression through the cell cycle. PIM kinases are upregulated in multiple cancer indications, including lymphoma, leukemia, multiple myeloma, and prostate, gastric, and head and neck cancers.
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- The receptor tyrosine kinase AXL is a promising target for cancer treatment due to its overexpression and role in tumor growth and metastasis.
- Researchers developed a homology model of AXL's catalytic domain to screen for small molecule inhibitors.
- They created a series of 2,4,5-trisubstituted pyrimidines that effectively inhibited AXL and reduced growth in pancreatic cancer cell lines, with an impressive IC(50) of 19 nM.