Publications by authors named "Lee Scott Weinstein"
Resistance to inhibitors of cholinesterases (ric-8 proteins) are involved in modulating G-protein function, but little is known of their potential physiological importance in the heart. In the present study, we assessed the role of resistance to inhibitors of cholinesterase 8b (Ric-8b) in determining cardiac contractile function. We developed a murine model in which it was possible to conditionally delete ric-8b in cardiac tissue in the adult animal after the addition of tamoxifen.
View Article and Find Full Text PDFPurpose: To compare the deoxyribonucleic acid (DNA) methylation signature of neuroendocrine tumors (NETs) by primary tumor site and inherited predisposition syndromes von Hippel-Lindau disease (VHL) and multiple endocrine neoplasia type 1 (MEN1).
Methods: Genome-wide DNA methylation (835 424 CpGs) of 96 NET samples. Principal components analysis (PCA) and unsupervised hierarchical clustering analyses were used to determine DNA methylome signatures.
Article Synopsis
- * The loss of the menin protein, caused by MEN1 mutations, is a significant factor in the development of these tumors and leads to an increase in the oncogenic receptor c-MET.
- * The review discusses clinical features, treatment options, and outcomes of GEP NETs, and highlights research on c-MET expression and potential treatments targeting c-MET as a precision-medicine strategy.