Machine Learning Algorithms to Predict the Risk of Rupture of Intracranial Aneurysms: a Systematic Review.

Purpose: Subarachnoid haemorrhage is a potentially fatal consequence of intracranial aneurysm rupture, however, it is difficult to predict if aneurysms will rupture. Prophylactic treatment of an intracranial aneurysm also involves risk, hence identifying rupture-prone aneurysms is of substantial clinical importance. This systematic review aims to evaluate the performance of machine learning algorithms for predicting intracranial aneurysm rupture risk.

Research for all: building a diverse researcher community for the All of Us Research Program.

Objectives: The NIH All of Us Research Program (All of Us) is engaging a diverse community of more than 10 000 registered researchers using a robust engagement ecosystem model. We describe strategies used to build an ecosystem that attracts and supports a diverse and inclusive researcher community to use the All of Us dataset and provide metrics on All of Us researcher usage growth.

Materials And Methods: Researcher audiences and diversity categories were defined to guide a strategy.

Underlying Mechanism of Electrolyte Compositional Engineering Based on Additive Solvation-Structure Governing Solid Electrolyte Interphase Formation in Lithium-Ion Batteries.

Substantial efforts are dedicated to optimizing the additive dosage in the electrolyte and studying its effect on solid electrolyte interphase (SEI) formation in Li-ion batteries (LIBs). This study reveals that the decomposition characteristics of the additive based on its lithium-ion solvation nature significantly contribute to controlling SEI formation. During SEI formation, the strong lithium-ion solvating additive spontaneously migrates to the negative electrode due to negative charge accumulation on the surface, and SEI reinforcement is feasible by increasing the additive dosage.

Development and environmental performance of a pilot-scale membrane capacitive deionization system for wastewater reclamation: Long-term operation and life cycle analysis.

Wastewater reclamation is regarded as a primary solution for efficient water resource management because of its environmental friendliness and energy efficiency. Membrane capacitive deionization (MCDI) has shown great promise as a practical technology for wastewater reclamation, but challenges remain for the large-scale deployment of this technology due to gaps in understanding its technical and environmental performance. This study presents a pilot-scale MCDI-based wastewater treatment and reclamation system that includes sand filtration (SF), ultrafiltration (UF), MCDI, and ultraviolet (UV) units.

Clinical outcomes of arthroscopic surgical intervention in femoroacetabular impingement amongst the Asian population: A meta-analysis.

Importance: In Asian populations, increased prevalence of hip dysplasia as well as activities of daily living which require increased hip range of motion, such as squatting, may impact outcomes of arthroscopic surgery for femoroacetabular impingement (FAI) when compared to their Western counterparts. Existing literature lacks a comprehensive review and synthesis of knowledge focusing on outcomes of arthroscopic intervention for FAI in the Asian population.

Objective: To conduct the first systematic review and meta-analysis that examines outcomes of arthroscopic intervention in Asian patients with FAI.

Interfacially Assembled Anion Exchange Membranes for Water Electrolysis.

High-performance and durable anion exchange membranes (AEMs) are critical for realizing economical green hydrogen production through alkaline water electrolysis (AWE) or AEM water electrosysis (AEMWE). However, existing AEMs require sophisticated fabrication protocols and exhibit unsatisfactory electrochemical performance and long-term durability. Here we report an AEM fabricated via a one-pot, in situ interfacial Menshutkin reaction, which assembles a highly cross-linked polymer containing high-density quaternary ammoniums and nanovoids inside a reinforcing porous support.

Phosphatidylserine-incorporated exosome mimetics encapsulating CXCR3 antagonist alleviate osteoporosis.

Exosomes derived from mesenchymal stem cells are an active area of research due to their therapeutic potential in treating osteoporosis. To further harness their therapeutic performance in modulating bone resorption, we have equipped exosomes with osteoclast-targeting moieties on their surface as well as chemokine receptor antagonists blocking osteoclast recruitment. Phosphatidylserine (PS), a membrane lipid exerting immunosuppressive and phagocytic signals, was incorporated in the membrane of exosome mimetics (EMs) to achieve a marked affinity for osteoclast precursors and potential anti-resorptive effects.

Effects of establishing infection control program with core components of World Health Organization on reducing the risk of residents' infections and improving staff infection control competency in a nursing home.

Background: Nursing homes (NHs) are high-risk facilities with limited infection control resources and residents susceptible to infectious diseases. The evidence regarding World Health Organization (WHO) core components in NHs is lacking. This study evaluates the effectiveness of establishing an infection prevention and control (IPC) program with WHO's core components in an NH.

Society of Surgical Oncology Breast Disease Site Working Group Statement on Bilateral Risk-Reducing Mastectomy: Indications, Outcomes, and Risks.

Bilateral risk-reducing mastectomy (BRRM) is the surgical removal of both breasts to reduce the risk of cancer. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, outcomes, and risks of BRRM to update the society's 2017 statement. We held a virtual meeting to outline key topics and conducted a literature search using PubMed to identify relevant articles.

Objective analysis of orbital rim fracture CT images using curve and area measurement.

The orbital bone presents a closed curve, and fracture results in disfigurement. An image analysis procedure was developed to examine before and after corrective surgery. An ellipse and circumscribed contour embodied the closed curve.

Feature-centric registration of large deformed images using transformers and correlation distance.

In deformable medical image registration, both a robust backbone registration network and a suitable similarity metric are essential. This paper introduces a robust registration network combined with a feature-based loss function, specifically designed to handle large deformations and address the challenge of the absence of ground truth data. Tackling large deformations typically requires either expanding the receptive field or breaking down extensive deformations into smaller, more manageable ones.

Magnetoelectric Coupling in a MnNa-Organic Complex under Pulsed Magnetic Fields up to 73 T.

Research on the magnetoelectric (ME) effect (or spin-electric coupling) in molecule-based magnetic materials is a relatively nascent but promising topic. Molecule-based magnetic materials have diverse magnetic functionalities that can be coupled to electrical properties. Here we investigate a realization of ME coupling that is fundamental but not heavily studied─the coupling of magnetic spin level crossings to changes in electric polarization.

INF2 mutations cause kidney disease through a gain-of-function mechanism.

Heterozygosity for inverted formin-2 (INF2) mutations causes focal segmental glomerulosclerosis (FSGS) with or without Charcot-Marie-Tooth disease. A key question is whether the disease is caused by gain-of-function effects on INF2 or loss of function (haploinsufficiency). Despite established roles in multiple cellular processes, neither INF2 knockout mice nor mice with a disease-associated point mutation display an evident kidney or neurologic phenotype.

Insecticide resistance and its intensity in urban Anopheles arabiensis in Kisumu City, Western Kenya: Implications for malaria control in urban areas.

Background: The rise of insecticide resistance poses a growing challenge to the effectiveness of vector control tools, particularly in rural areas. However, the urban setting has received comparatively less focus despite its significance in attracting rural to urban migration. Unplanned urbanization, often overlooked, exacerbates insecticide resistance as Anopheles mosquitoes adapt to the polluted environments of rapidly expanding cities.

Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal.

Purpose: We tested whether the PARP inhibitor, Olaparib, can effectively enhance radiosensitivity while inhibiting OSCC growth and metastasis in vitro and in vivo. Patient samples were used for survival validation.

Methods: The present study investigated the effect of Olaparib and ionizing radiation (IR) on clonogenic, migratory, and invasive ability in human IR-sensitive (OML1) and IR-resistant (OML1-R) OSCC cell lines.

Long-term Outcomes After Total Ankle Arthroplasty: A Systematic Review.

Background: Total ankle arthroplasty has emerged as a treatment to successfully treat ankle arthritis. Recent studies have reported more than 40 000 total ankle arthroplasties (TAAs) being performed between 2009 and 2019 in the United States. Although recent studies have reported favorable patient-reported outcomes at short- and midterm follow-up, there is a paucity of aggregate literature reporting on long-term patient-reported outcomes (PROs) after TAA.

The experiences of visually impaired military veterans with Charles Bonnet syndrome.

Background: Charles Bonnet syndrome (CBS) refers to the experience of visual hallucinations occurring secondary to sight loss. Although there is an increasing amount of research on this phenomenon, CBS remains a lesser-known outcome of visual impairment, with limited research into the impact on the patient.

Objectives: To explore the experiences and opinions of visually impaired military veterans with CBS regarding the impact of visual hallucinations.

LY-2183240 enhances reward-seeking behavior with inducing neuronal excitation and early apoptosis in mouse.

Cannabinoids interact with cannabinoid receptors, influencing diverse central nervous system (CNS) and peripheral functions, including anxiety, depression, and cognition. CB1 and CB2 receptors modulate signaling cascades via G-protein coupling, with anandamide acting as an endogenous ligand for CB1 receptors. LY-2183240, a putative endocannabinoid transport blocker, elevates brain anandamide levels, showing therapeutic potential in pain management and alcohol-related behaviors.

Pulmonary Delivery of Anti-microRNA Oligonucleotide and Glycyrrhizic Acid Using Ternary Peptide Micelles for the Treatment of Acute Lung Injury.

Acute lung injury (ALI) is a devastating inflammatory disease. In lungs with inflammation, microRNA155 (miR155) induces inflammatory cytokines by inhibiting the expression of suppressor of cytokine signaling-1 (SOCS1). In addition, glycyrrhizic acid (GA) has been suggested as an anti-inflammatory drug for ALI, since it is an efficient inhibitor of nuclear factor-κB.

RNA sequencing of Beauveria bassiana JEF-350-infected Thrips palmi reveals change of host defense and homeostasis.

Melon thrips, Thrips palmi, represent a significant threat to plants, inducing necrosis and acting as vectors for numerous plant viruses. Entomopathogenic fungi present a promising avenue for the management of melon thrips populations resistant to conventional chemical treatments. In this work, an adult colony of melon thrips was exposed to Beauveria bassiana strain JEF-350, and the ensuing transcriptional response of the infected thrips was scrutinized to elucidate their reactions during fungal pathogenesis.

Differential effect on labor force health initiated by the first wave of the COVID-19 in Taiwan.

The 2019 coronavirus disease pandemic disrupts synchronized lifestyles and influences an individual's health status. However, Taiwan has limited studies on the impact of the epidemic on the health and lifestyle of its citizens. This study aims to investigate the impact on lifestyle and health status during the first wave of 2019 coronavirus disease in Taiwan.

Hospital Dental Admissions and Caries Experience Among Children With Neurodevelopmental Disabilities: A Population-Based Record Linkage Cohort Study.

Background: Within Aotearoa | New Zealand, rates of largely preventable severe caries and dental hospitalisations among children are increasing and inequalities exist. However, little population-based empirical evidence exists describing this oral health burden among children with neurodevelopmental disabilities (NDDs). This study aimed to estimate and compare the rates of dental hospital admissions in a near-national population of children aged ≤ 14 years with attention-deficit hyperactivity disorder, autism, intellectual disability or any NDD after accounting for key confounding variables.