Publications by authors named "Lee I-Min"
Background: Blood pressure (BP)-lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast walking, and combined exercise-like activity [eg, running and cycling]) and systolic BP (SBP) and diastolic BP (DBP).
View Article and Find Full Text PDFBackground: Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D and marine omega-3 fatty acids (n-3 FA) may improve insulin resistance. We sought to examine the association between baseline levels of insulin, C-peptide, HbA1c, and a novel insulin resistance score (IRS) with incident cardiometabolic diseases, and whether randomized vitamin D or n-3 FA modify these associations.
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- Physical activity (PA) both before and after a cancer diagnosis can lower the risk of mortality in cancer patients, as shown in studies involving large cohorts like the Women's Health Study and the Physicians' Health Study.
- Participants who remained active or became active after their diagnosis showed significantly lower risks for all-cause, cancer-specific, and non-cancer-related mortality compared to those who remained inactive.
- The findings suggest that encouraging physical activity in cancer patients might enhance survival, but further research is necessary to confirm these benefits across different types of cancers.
Background: Data on the relation of potato consumption with risk of type 2 diabetes (T2D) are limited and inconsistent. It is unclear whether the plant-based diet index (PDI), which is a novel and comprehensive tool to assess overall dietary pattern, modifies the association of potato intake with T2D.
Objectives: We examined the association of total, combined baked, boiled, and mashed potatoes and fried potatoes with risk of T2D and test the interaction between PDI score and potato consumption on T2D risk.
Background: High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction method.
Methods: We measured high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels at baseline in 27,939 initially healthy U.
Introduction: It is unclear whether moderate-to-vigorous physical activity (MVPA) is associated with a lower mortality risk, over and above its contribution to total physical activity volume.
Methods: 46,682 adults (mean age: 64 years) were included in a meta-analysis of nine prospective cohort studies. Each cohort generated tertiles of accelerometry-measured physical activity volume and volume-adjusted MVPA.
Objective: Accumulating more steps/day is associated with a lower risk of cancer mortality and composite cancer outcomes. However, less is known about the relationship of steps/day with the risk of multiple site-specific cancers.
Methods: This study included >22,000 women from the Women's Health Accelerometry Collaboration Cohort (2011-2022), comprised of women from the Women's Health Study and Women's Health Initiative Objective Physical Activity and Cardiovascular Health Study.
Article Synopsis
- This study investigates how different levels of physical activity can reduce the negative effects of sedentary behavior on mortality rates, particularly focusing on all-cause and cardiovascular disease (CVD) mortality.
- Researchers analyzed data from 73,729 adults using accelerometers to measure sedentary time and varying intensities of physical activity over roughly 6.9 years, identifying significant mortality outcomes.
- Findings suggest that engaging in at least 6 minutes of vigorous, 30 minutes of moderate-to-vigorous, 64 minutes of moderate, or 163 minutes of light physical activity daily can help mitigate the mortality risks associated with high sedentary time.
Importance: Higher adherence to the Mediterranean diet has been associated with reduced risk of all-cause mortality, but data on underlying molecular mechanisms over long follow-up are limited.
Objectives: To investigate Mediterranean diet adherence and risk of all-cause mortality and to examine the relative contribution of cardiometabolic factors to this risk reduction.
Design, Setting, And Participants: This cohort study included initially healthy women from the Women's Health Study, who had provided blood samples, biomarker measurements, and dietary information.
Background: Patterns of physical activity and sedentary behavior among postmenopausal women are not well characterized.
Objectives: To describe the patterns of accelerometer-assessed physical activity and sedentary behavior among postmenopausal women.
Design: Cross-sectional study.
Importance: Current US physical activity (PA) guidelines prescribe moderate to vigorous PA (MVPA) time of at least 150 minutes per week for health. An analogous step-based recommendation has not been issued due to insufficient evidence.
Objective: To examine the associations of MVPA time and step counts with all-cause mortality and cardiovascular disease (CVD).
Background: Describing correlates of physical activity (PA) and sedentary behavior (SB) among postmenopausal cancer survivors can help identify risk profiles and can be used to support development of targeted interventions to improve PA and reduce SB in this population.
Objective: To describe PA/SB and identify correlates of PA/SB among cancer and cancer-free post-menopausal women.
Methods: Women from the Women's Health Study (N = 16,629) and Women's Health Initiative/Objective Physical Activity and Cardiovascular Health Study (N = 6,079) were asked to wear an accelerometer on the hip for 7 days.
Context: Declining muscle strength and performance in older adults are associated with falls, fractures, and premature death.
Objective: This work aimed to determine whether supplementation with vitamin D3 or omega-3 fatty acids vs placebo for 2 years improves physical performance measures.
Methods: VITamin D and OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled randomized trial of supplemental vitamin D3 and/or omega-3 fatty acids vs placebo in the prevention of cancer and cardiovascular disease in 25 871 US adults.
Aims/hypothesis: The aim of this study was to examine the dose-response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health.
Methods: We conducted an individual participant harmonised meta-analysis of 12,095 adults (mean ± SD age 54.5±9.
Objectives: This study aims to examine the associations of daily step count with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels and to determine if the minimal and optimal number of daily steps is modified by high sedentary time.
Methods: Using data from the UK Biobank, this was a prospective dose-response analysis of total daily steps across low (<10.5 hours/day) and high (≥10.
Background: We examined the joint associations of diet and device-measured intensity-specific physical activity (PA) with all-cause mortality (ACM), cardiovascular disease (CVD), and cancer incidence.
Methods: We used data from 79,988 participants from the UK Biobank, a population-based prospective cohort study. Light PA (LPA), moderate-to-vigorous PA (MVPA), vigorous PA (VPA), and total PA (TPA) were measured using a wrist-worn accelerometer.
Background: Blueberries and anthocyanins, their key bioactive component, may improve eye health. However, few long-term studies have examined blueberries and anthocyanins with cataract and age-related macular degeneration (AMD).
Objectives: To investigate the prospective association between blueberry and anthocyanin intake with incident cataract, total AMD, and visually significant AMD among middle-aged and older women.
Alcohol intake is associated with breast cancer (BC) risk, but estimates of greatest public health relevance have not been quantified in large studies with long duration. In this prospective cohort study of 39,811 women (median 25 years follow-up), we examined the association between alcohol consumption and BC incidence and mortality with adjusted hazard ratios (HRs), cubic splines, absolute risks, number needed to harm (NNH), and population-attributable fractions. We documented 2,830 cases of BC, including 237 BC deaths.
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- Higher prepandemic physical activity (PA) levels are linked to a lower risk and severity of COVID-19, highlighting the importance of regular exercise before the pandemic.
- The study examined the relationship between self-reported prepandemic PA and COVID-19 outcomes in older US adults, involving over 61,000 participants aged 45 and older, tracked through surveys from May 2020 to May 2022.
- Results indicated that insufficiently active individuals did not experience a significant reduction in COVID-19 infection or hospitalization risk compared to those who were inactive, suggesting that only higher levels of PA may confer benefits.
Objectives: The objective was to investigate the benefits of the 'weekend warrior' physical activity pattern in Latin America, where many people take part in high levels of non-exercise physical activity.
Methods: Participants in the Mexico City Prospective Study were surveyed from 1998 to 2004 and resurveyed from 2015 to 2019. Those who exercised up to once or twice per week were termed weekend warriors.
Objective: In the 5.3-year randomized, 2 × 2 factorial, double-blind, placebo-controlled Vitamin D and Omega-3 Trial (VITAL), vitamin D supplementation reduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval [CI] 0.
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- The study evaluated the impact of daily vitamin D supplementation on reducing the risk of upper respiratory infections (URI) in older adults with varying levels of vitamin D.
- It involved over 15,000 participants in a randomized trial comparing vitamin D3 (2000 IU/day) to a placebo, focusing on self-reported URI incidents over one year.
- Results showed no significant difference in URI risk overall, even among those with low initial vitamin D levels, indicating the need for further research to explore potential subgroup effects.*
Article Synopsis
- The study analyzed data from over 1 million women across various regions to explore the relationship between reproductive and hormonal factors and the risk of differentiated thyroid cancer (DTC).
- Findings indicated that certain factors, such as younger age at menarche and menopause, use of hormone therapy, and previous surgeries like hysterectomy, were associated with an increased risk of DTC, while long-term oral contraceptive use and being post-menopausal were linked to a lower risk.
- The researchers caution that the associations identified are relatively weak and recommend further studies to clarify the effects of sex steroid hormones on DTC risk.