Comprehensive Stress Stability Studies Reveal the Prominent Stability of the Liquid-Formulated Biotherapeutic Asymmetric Monovalent Bispecific IgG1 Monoclonal Antibody Format.

The developed asymmetric monovalent bispecific IgG1 or Duet monoclonal antibody (Duet mAb) has two distinct fragment antigen-binding region (Fab) subunits that target two different epitope specificities sequentially or simultaneously. The design features include unique engineered disulfide bridges, knob-into-hole mutations, and kappa and lambda chains to produce Duet mAbs. These make it structurally and functionally complex, so one expects challenging developability linked to instability, degradation of products and pathways, and limited reports available.

Navigating Chinese cities to achieve sustainable development goals by 2030.

Achieving the 17 United Nations sustainable development goals (SDGs) in China largely depends on the transition of cities toward sustainable development. However, significant knowledge gaps exist in evaluating the SDG index at the city scale and in understanding how to simulate pathways to achieve the 17 SDGs for Chinese cities by 2030. This study aimed to quantify the SDG index of 285 Chinese cities and developed a forecasting model to simulate the performance of each SDG in each city until 2030 using varied scenarios.

Ensemble Capsule Network with an Attention Mechanism for the Fault Diagnosis of Bearings from Imbalanced Data Samples.

In order to solve the problem of imbalanced and noisy data samples for the fault diagnosis of rolling bearings, a novel ensemble capsule network (Capsnet) with a convolutional block attention module (CBAM) that is based on a weighted majority voting method is proposed in this study. Firstly, the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) method was used to decompose the raw vibration signal into different IMF signals, which are noise reduction signals. Secondly, the IMF signals were input into the Capsnet with CBAM in order to diagnose the fault category preliminarily.

A Blockchain-IoT Platform for the Smart Pallet Pooling Management.

Pallet management as a backbone of logistics and supply chain activities is essential to supply chain parties, while a number of regulations, standards and operational constraints are considered in daily operations. In recent years, pallet pooling has been unconventionally advocated to manage pallets in a closed-loop system to enhance the sustainability and operational effectiveness, but pitfalls in terms of service reliability, quality compliance and pallet limitation when using a single service provider may occur. Therefore, this study incorporates a decentralisation mechanism into the pallet management to formulate a technological eco-system for pallet pooling, namely Pallet as a Service (PalletaaS), raised by the foundation of consortium blockchain and Internet of things (IoT).

A stochastic network design problem for hazardous waste management.

Hazardous waste management is of paramount importance due to the potential threats posed to the environment and local residents. The design of a hazardous waste management system involves several important decisions, i.e.

A Survey of Knowledge and Attitudes of Nurses About Pain Management in End-Stage Liver Disease in a Geriatric Palliative Care Unit.

Background: Palliative care is often initiated late for patients with end stage liver disease (ESLD) with pain being a common morbidity that is under-treated throughout the disease trajectory. When admitted to a palliative care unit (PCU), nurses play a pivotal role and must be highly informed to ensure effective pain management. The aim of this study is to determine the baseline level of knowledge and attitudes of PCU nurses regarding pain management in patients with ESLD.