Topography-Guided Custom Ablation Photorefractive Keratectomy Treatment of Irregular Astigmatism Resulting From Decentered SMILE.

Purpose: To describe the use of topography-guided custom ablation treatment with photorefractive keratectomy (T-CAT PRK) to correct irregular astigmatism and visual aberrations resulting from decentered small incision lenticule extraction (SMILE).

Methods: Case report and literature review.

Results: A 41-year-old woman experienced blurred uncorrected distance acuity (UDVA), reduced corrected distance acuity (CDVA), and monocular diplopia in one eye following SMILE due to treatment decentration.

Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis.

Ichthyosis is a cutaneous disorder characterized by excessive amounts of dry thickened skin surface scales. Ocular manifestations of ichthyosis include cicatricial ectropion, which may cause exposure keratoconjunctivitis and rarely corneal perforation. Topical emollients, anti-inflammatory ointments, and systemic retinoids have been used to control the disease process, while surgical correction with donor graft has been reserved for severe cases involving corneal exposure.

Bacterial biofilm diversity in contact lens-related disease: emerging role of Achromobacter, Stenotrophomonas, and Delftia.

Purpose: Multi-species biofilms associated with contact lens cases and lenses can predispose individuals to contact lens-related inflammatory complications. Our study used culture-independent methods to assess the relationship between the severity of contact lens-related disease and bacteria residing in biofilms of contact lens cases and lenses.

Methods: Contact lens cases and lenses from 28 patients referred to the West Virginia University Eye Institute and diagnosed as having mild keratitis, keratitis with focal infiltrates, or corneal ulcers were processed and evaluated for bacterial composition based on 16S ribosomal RNA gene sequencing.

Microkeratome-assisted anterior lamellar keratoplasty.

Microkeratome-assisted anterior lamellar keratoplasty has emerged as a surgical option for conditions affecting the clarity of the outer 200 mum of the cornea. Herein we describe the outcome of a simple procedure in which the excimer laser can be used to augment deep tissue removal after both recipient bed and donor graft are prepared with the microkeratome. Our noncomparative interventional case series involved 5 eyes of 4 patients with lattice corneal dystrophy who underwent microkeratome-assisted anterior lamellar keratoplasty.

Predictability of donor lamellar graft diameter and thickness in an artificial anterior chamber system.

Purpose: To identify factors affecting the predictability and report results of donor lamellar graft diameter and thickness in an artificial anterior chamber obtained with a microkeratome.

Methods: Lamellar lenticules were obtained from 25 human corneoscleral rims mounted in an artificial anterior chamber. Lenticules measuring 9 mm were attempted at two thicknesses (250 microm and 350 microm heads).

Tectonic lamellar keratoplasty utilizing a microkeratome and an artificial anterior chamber system.

Purpose: To describe a technique and report results of tectonic lamellar keratoplasty using tissue harvested with a microkeratome from a corneoscleral rim mounted in an artificial anterior chamber system.

Methods: A donor lenticule was prepared from a corneoscleral rim utilizing the Moria LSK-1 (Moria/Microtek Inc., Doylestown, PA, U.