Publications by authors named "Leclercq C"

Background: Following implantation/replacement of an implantable cardioverter-defibrillator, patients are legally subjected to variable lengths of driving restrictions based on the indication (1 and 3 months after primary and secondary prevention, respectively; 1 week after device replacement).

Aim: To assess the incidence of ventricular arrhythmia during the theoretical driving restriction period in a large cohort of patients.

Methods: Patients who underwent implantable cardioverter-defibrillator implantation for primary or secondary prevention or device replacement between 2015 and 2021 were included retrospectively.

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Article Synopsis
  • Heart rhythm and conduction disorders vary in severity and can be benign or life-threatening, with a focus on their epidemiology in France.
  • A study analyzed hospitalization data from 2022 and mortality from 2021 to assess the prevalence of three main conditions: atrial fibrillation/flutter, conduction disorders, and ventricular tachycardia/cardiac arrest.
  • Findings revealed over 2.7 million individuals impacted by these disorders as of January 2023, with significant hospitalization rates and a concerning 44% mortality rate for those hospitalized due to ventricular tachycardia/cardiac arrest.
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Atrial fibrillation (AF) is the primary cause of ischaemic stroke and transient ischaemic attack (TIA). AF is associated with a high risk of recurrence, which can be reduced using optimal prevention strategies, mainly anticoagulant therapy. The availability of effective prophylaxis justifies the need for a significant, coordinated and thorough transdisciplinary effort to screen for AF associated with stroke.

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  • The study introduces a new technique called multielectrode catheter-induced ectopy mapping (MECIE mapping) to help locate the origins of infrequent premature ventricular complexes (PVCs) for effective ablation treatment.
  • Researchers enrolled 29 patients with infrequent PVCs and used MECIE mapping to create a detailed local activation time map, achieving high concordance with the clinical PVCs.
  • After an average follow-up of about 13 months, 93.1% of the patients experienced an 80% or greater reduction in PVCs, indicating that MECIE mapping is a promising strategy for successful PVC ablation.
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  • Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome that can occur in individuals with genetic predispositions or in immunocompromised patients, though it’s particularly rare in solid organ transplant recipients, such as lung transplant patients.
  • This case study presents an unusual incident of HLH developing 11 years after lung transplantation in a 67-year-old patient, with symptoms including pancytopenia, fever, and splenomegaly, and showed signs of post-transplant lymphoproliferative disorder (PTLD).
  • Despite treatment with etoposide, corticosteroids, and rituximab, the patient ultimately died from complications, highlighting the need for
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  • The ECOST-CRT study assessed whether integrating a comprehensive remote monitoring (RM) scheme into heart failure (HF) care could improve patient outcomes compared to standard RM methods.
  • 652 patients with cardiac resynchronization therapy (CRT) devices were split into two groups: one receiving only standard monitoring and the other receiving additional symptom tracking and notifications.
  • Despite finding better quality of life improvements in the comprehensive RM group, the study did not show a significant difference in all-cause mortality or hospitalizations for worsening heart failure, partly due to early termination caused by the COVID-19 pandemic.
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  • This study looks at how well doctors can predict sudden cardiac death after someone has a heart attack using a measurement called left ventricular ejection fraction (LVEF).
  • They combined information from over 140,000 heart attack patients to see if LVEF alone is good enough for deciding who should get a heart device called a defibrillator.
  • The results showed that LVEF didn't do a great job at predicting sudden cardiac death, which means doctors need better ways to tell who is at risk.
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  • The study evaluates the long-term performance and safety of the extravascular implantable cardioverter-defibrillator (EV ICD) after initial findings showed its effectiveness for 6 months.
  • A total of 316 patients were enrolled, with a successful implant in 299 cases, experiencing various arrhythmic events that were effectively treated using antitachycardia pacing (ATP) and shocks.
  • The results indicated high success rates for both ATP (77.1%) and shock therapy (100%), with low rates of complications and inappropriate shocks over the three-year study period.
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  • The study evaluated the CardioMEMS™ HF System in 103 French patients to assess its feasibility, safety, and clinical benefits post-implantation.
  • Over two years, no device-related complications were reported, and the system showed a 50% reduction in heart failure hospitalizations compared to the year before implantation.
  • Additionally, patients experienced lower pulmonary artery pressures and improvements in their functional class and overall quality of life.
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Background And Aims: Prophylactic implantable cardioverter-defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e.

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Purpose: Eosinophilic otitis media (EOM) is a difficult-to-treat otitis media characterized by eosinophilic accumulation in the middle ear mucosa and effusion. It is refractory to conventional treatments and is strongly associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The diagnostic criteria for EOM were established by IINO in 2011.

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Atrial fibrillation (AF) is the primary cause of ischaemic stroke and transient ischaemic attack (TIA). AF is associated with a high risk of recurrence, which can be reduced using optimal prevention strategies, mainly anticoagulant therapy. The availability of effective prophylaxis justifies the need for a significant, coordinated and thorough transdisciplinary effort to screen for AF associated with stroke.

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Aims: The extravascular implantable cardioverter-defibrillator (EV ICD) has been shown to be safe and effective for patients at risk of sudden cardiac death, but little is known about EV ICD lead removal in humans. This analysis aimed to characterize the EV ICD lead removal experience thus far.

Methods And Results: This was a retrospective analysis of lead removals from the EV ICD Pilot, Pivotal, and Continued Access Studies.

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Diets, but also overall food environments, comprise a variety of significant factors with direct and indirect impacts on human health. Eco-Regions are geographical areas with a territorial approach to rural development, utilizing organic food and farming practices, and principles and promoting sustainable communities and food systems. However, so far, little attention has been given to quantifying aspects of the health of citizens living in these sustainable transition territories.

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Quinidine, the first antiarrhythmic drug, was widely used during the 20th century. Multiple studies have been conducted to provide insights into the pharmacokinetics and pleiotropic effects of Class Ia antiarrhythmic drugs. However, safety concerns and the emergence of new drugs led to a decline in their use during the 1990s.

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Background: Studies have reported that female sex predicts superior cardiac resynchronization therapy (CRT) response. One theory is that this association is related to smaller female heart size, thus increased relative dyssynchrony at a given QRS duration (QRSd). Our objective was to investigate the mechanisms of sex-specific CRT response relating to heart size, relative dyssynchrony, cardiomyopathy type, QRS morphology, and other patient characteristics.

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  • The study investigates the effectiveness of atrioventricular optimization (AVO) algorithms in cardiac resynchronization therapy (CRT), particularly for patients with interventricular delays of 70 ms or more, combining data from the SMART-AV and SMART-CRT trials for increased statistical power.
  • Results show that patients using the SmartDelay AVO algorithm had a higher CRT response rate (73.9%) compared to those with a fixed AV delay (63.1%), indicating better heart function improvement.
  • The findings suggest that SmartDelay is beneficial for CRT patients with significant interventricular delays, advocating for its use in clinical practice.
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This article reviews the recent advances or nerve-oriented surgical procedures in the treatment of the spastic upper limb. The idea to intervene on the nerve is not recent, but new trends have developed in nerve surgery over the past few years, stimulating experiments and research. Specific surgical procedures involving the nerves have been described at different levels from proximal to distal: at the cervical spinal cord and the dorsal root entry zone (rhizotomy), at the level of the roots (contralateral C7 transfer) or in the peripheral nerve, within the motor trunk (selective neurectomy) or as its branches penetrate the muscles (hyperselective neurectomy).

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Seaweeds, including the green Ulva lactuca, can potentially reduce competition between feed, food, and fuel. They can also contribute to the improved development of weaned piglets. However, their indigestible polysaccharides of the cell wall pose a challenge.

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In nature, plants are exposed to a range of climatic conditions. Those negatively impacting plant growth and survival are called abiotic stresses. Although abiotic stresses have been extensively studied separately, little is known about their interactions.

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Objectives: There is a progressive reduction in the rate of episiotomies since the recommendations of the French college of gynaecologists. Our objective was to study the evolution of the rate of episiotomies and Obstetric Anus Sphincter Injury (OASI) since the restriction of episiotomies in our department.

Methods: Observational monocentric retrospective study performed at the Rouen University Hospital.

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