Gallatabenzene Ligands Emerging from Open Lutetocene and Yttrocene Methyl Complexes.

Utilizing ternary mixtures [LnMe]/K(2,4-dtbp)/GaMe (Ln=Lu, Y; 2,4-dtbp=2,4-di-tert-butyl-pentadienyl), a series of metallacycles is accessible via tandem salt metathesis/deprotonation. Depending on the precursor molar ratio, both gallatabenzene and lutetacyclic moieties with fully planar metallacycles are obtained, which were further analyzed using DFT calculations. The precursor molar ratio affects the extent of pentadienyl C-H-bond activation and oligomerization to tetra- and pentametallic arrays.

Continuous Right Ventricular Pressure Monitoring in Cardiac Surgery.

Objective: Right ventricular (RV) dysfunction in cardiac surgery can lead to RV failure, which is associated with increased morbidity and mortality. Abnormal RV function can be identified using RV pressure monitoring. The primary objective of the study is to determine the proportion of patients with abnormal RV early to end-diastole diastolic pressure gradient (RVDPG) and abnormal RV end-diastolic pressure (RVEDP) before initiation and after cardiopulmonary bypass (CPB) separation.

4S-fluorination of ProB29 in insulin lispro slows fibril formation.

Recombinant insulin is a life-saving therapeutic for millions of patients affected by diabetes mellitus. Standard mutagenesis has led to insulin variants with improved control of blood glucose; for instance, the fast-acting insulin lispro contains two point mutations that suppress dimer formation and expedite absorption. However, insulins undergo irreversible denaturation, a process accelerated for the insulin monomer.

Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury.

Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal cells remains elusive. Here, from adult mice, we identify a near homogenous population of ductal progenitor-like clusters, with an average of 8 cells per cluster. They are a rare subpopulation, about 0.

Yttrium Complexes with Group 13 Heterobenzene-Type Ligands.

The yttrium gallabenzene complex [(1-Me-3,5-tBu -C H Ga)(μ-Me)Y(2,4-dtbp)] is accessible from Y(GaMe ) and K(2,4-dtbp) via a tandem salt metathesis/methane elimination (2,4-dtbp=2,4-di-tert-butyl-pentadienyl). The pentadienyl ligand in [(1-Me-3,5-tBu -C H E)(μ-Me)Y(2,4-dtbp)] (E=Al, Ga) is easily displaced by salt metathesis with KC Me and KTp (Tp =tris(pyrazolyl-Me -3,5)borato) affording [(1-Me-3,5-tBu -C H E)(μ-Me)Y(Tp )] and [(1-Me-3,5-tBu -C H E)(μ-Me)Y(C Me )]. The yttrium center in [(1-Me-3,5-tBu -C H E)(μ-Me)Y(2,4-dtbp)] readily forms adducts with neutral Lewis bases like 4-DMAP (4-dimethylaminopyridine), PMe , DMPE (1,2-bis(dimethylphosphino)ethane), and DME (1,2-dimethoxyethane).

Early prediction of ventricular fibrillation using electrocardiographic characteristics in prehospital suspected ST-segment elevation myocardial infarction: a case-control study.

Purpose: Our objective was to determine characteristics of electrocardiograms (ECG) that predict ventricular fibrillation (VF) among prehospital patients with suspected ST-segment elevation myocardial infarction (STEMI) in Québec.

Methods: We performed a matched case-control study of prehospital adult suspected with STEMI. Patients in case group (STEMI/VF+) were matched with controls (STEMI/VF-) for age and sex and then compared for ECG characteristics, including ST-segment elevations (STE) and depressions (STD), duration of interval complexes, general characteristics, and several calculated variables.

Rare-earth-metal trimethylsilylmethyl ate complexes.

En route to putative rare-earth-metal alkylidene complex Li[Lu(CHSiMe)(CHSiMe)], according to Schumann's original protocol, the reaction of YCl with LiCHSiMe in a mixture of diethyl ether and -pentane afforded a neosilyl ate complex of composition LiY(CHSiMe). Tetrametallic complex LiY(CHSiMe) shows an unprecedented structural motif in the solid state and was further characterized by heteronuclear H/C/Li/Si/Y, as well as VT NMR and DRIFT spectroscopies. Analysis of the thermolysis product heteronuclear NMR spectroscopy and its reactivity towards benzophenone gave strong evidence for an alkylidene formation upon decomposition.

Schlenk's Legacy-Methyllithium Put under Close Scrutiny.

Commercially available stock solutions of organolithium reagents are well-implemented tools in organic and organometallic chemistry. However, such solutions are inherently contaminated with lithium halide salts, which can complicate certain synthesis protocols and purification processes. Here, we report the isolation of chloride-free methyllithium employing K[N(SiMe ) ] as a halide-trapping reagent.

Early Detection and Correction of Cerebral Desaturation With Noninvasive Oxy-Hemoglobin, Deoxy-Hemoglobin, and Total Hemoglobin in Cardiac Surgery: A Case Series.

Regional cerebral oxygen saturation (rS o2 ) obtained from near-infrared spectroscopy (NIRS) provides valuable information during cardiac surgery. The rS o2 is calculated from the proportion of oxygenated to total hemoglobin in the cerebral vasculature. Root O3 cerebral oximetry (Masimo) allows for individual identification of changes in total (ΔcHbi), oxygenated (Δ o2 Hbi), and deoxygenated (ΔHHbi) hemoglobin spectral absorptions.

Reliable and Scalable SARS-CoV-2 qPCR Testing at a High Sample Throughput: Lessons Learned from the Belgian Initiative.

We present our approach to rapidly establishing a standardized, multi-site, nation-wide COVID-19 screening program in Belgium. Under auspices of a federal government Task Force responsible for upscaling the country's testing capacity, we were able to set up a national testing initiative with readily available resources, putting in place a robust, validated, high-throughput, and decentralized qPCR molecular testing platform with embedded proficiency testing. We demonstrate how during an acute scarcity of equipment, kits, reagents, personnel, protective equipment, and sterile plastic supplies, we introduced an approach to rapidly build a reliable, validated, high-volume, high-confidence workflow based on heterogeneous instrumentation and diverse assays, assay components, and protocols.

Intra-abdominal pressure during and after cardiac surgery: a single-centre prospective cohort study.

Purpose: While intra-abdominal hypertension (IAH) has been associated with adverse outcomes in multiple settings, the epidemiology and clinical implications of IAH in the context of cardiac surgery are less known. In this study, we aimed to describe the prevalence of IAH in patients undergoing cardiac surgery and determine its association with patient characteristics and postoperative outcomes.

Methods: We conducted a single-centre prospective cohort study in which intra-abdominal pressure was measured in the operating room after general anesthesia (T1), after the surgical procedure (T2), and two hours after intensive care unit (ICU) admission (T3) in a subset of patients.

CeCl /n-BuLi: Unraveling Imamoto's Organocerium Reagent.

CeCl (thf) reacts at low temperatures with MeLi, t-BuLi, and n-BuLi to isolable organocerium complexes. Solvent-dependent extensive n-BuLi dissociation is revealed by Li NMR spectroscopy, suggesting "Ce(n-Bu) (thf) " or solvent-separated ion pairs like "[Li(thf) ][Ce(n-Bu) (thf) ]" as the dominant species of the Imamoto reagent. The stability of complexes Li Ln(n-Bu) (thf) increases markedly with decreasing Ln size.

Remote certification of out-of-hospital deaths in a Canadian Province: An 8-year experience of a novel practice.

Introduction: Certification of out-of-hospital deaths is challenging as physicians are often unavailable at the scene. In these situations, emergency medical services will generally transport the decedent to the nearest hospital. In 2011, a remote death certification program was implemented in the province of Québec, Canada.

Endovascular Vena Cavae Occlusion Technique in Minimally Invasive Tricuspid Valve Surgery in Patients With Previous Cardiac Surgery.

Objectives: The aim of the present study was to describe a bicaval endovascular occlusion technique in minimally invasive tricuspid valve (TV) surgery in patients with previous cardiac surgery.

Design: Case series.

Setting: Single tertiary university center.

Contemporary outcomes of aortic and mitral valve surgery for rheumatic heart disease in sub-Saharan Africa.

Objectives: Rheumatic heart disease is endemic in sub-Saharan Africa. There is a paucity of data on the outcomes of valvular surgery for rheumatic heart disease in the developing world. The objective of this study was to evaluate the outcomes of aortic and mitral valve surgery for rheumatic heart disease in Ethiopia.

In Vivo Protamine Titration Using Activated Coagulation Time to Neutralize Heparin Anticoagulation in Cardiac Surgery: Proof of Concept.

Objective: In vivo protamine titration (IVPT) is based on the observation of a plateau on the decay curve of the celite activated clotting times (ACTs) during protamine infusion for heparin reversal. The aim of the present study was to determine the optimal protamine/heparin ratio to reverse anticoagulation using IVPT curves.

Design: Prospective, randomized study.

Intranasal Fentanyl versus Subcutaneous Fentanyl for Pain Management in Prehospital Patients with Acute Pain: A Retrospective Analysis.

: Retrospective analysis evaluating and comparing the feasibility, effectiveness and safety of intranasal fentanyl (INF) and subcutaneous fentanyl (SCF) for pain management of patients with acute severe pain in a rural/suburban Emergency Medical Services (EMS) system. : Pre- and post-pain management data of all patients (aged ≥14 years) who were transported to the emergency department (January 2015-August 2017) were extracted from EMS and online medical control center records, and compared for groups receiving INF or SCF. Kaplan-Meier analysis and the log-rank test were used to describe and compare the percentage of patients in both groups who experienced relief according to their clinically significant pain relief score.

Venoarterial Extracorporeal Membrane Oxygenation Support for Severe Pericardial Decompression Syndrome: A Case Report.

Objectives: We report a case of a man with tamponade decompression syndrome following pericardial drainage.

Data Sources: ICU - Montreal Heart Institute.

Study Selection: Case report.

Pentadienyl migration and abstraction in yttrium aluminabenzene complexes including a single-component catalyst for isoprene polymerization.

Aluminabenzene complex [(1-Me-3,5-tBu2-C5H3Al)(μ-Me)Y(2,4-dtbp)] (2,4-dtbp = 2,4-di-tert-butylpentadienyl) reacts with LiN(SiHMe2)2 according to a methyl/silylamido exchange and formation of [(1-Me-3,5-tBu2-C5H3Al){μ-N(SiHMe2)2}Ln(2,4-dtbp)] which engages in a donor(THF)-dependent reversible Ln-to-Al-pentadienyl migration. The reaction of [(1-Me-3,5-tBu2-C5H3Al)(μ-Me)Y(2,4-dtbp)] with [CPh3][B(C6F5)4] results in pentadienyl group abstraction affording cationic complex [(1-Me-3,5-tBu2-C5H3Al)(μ-Me)Y(benzene)][B(C6F5)4] which acts as a single-component catalyst in isoprene polymerization.

Myocardial Protection in Minimally Invasive Mitral Valve Surgery: Retrograde Cardioplegia Alone Using Endovascular Coronary Sinus Catheter Compared With Combined Antegrade and Retrograde Cardioplegia.

Objective: To compare myocardial protection with retrograde cardioplegia alone with antegrade and retrograde cardioplegia in minimally invasive mitral valve surgery (MIMS).

Design: Retrospective study.

Setting: Tertiary care university hospital.

[The Need for Recovery Scale: French adaptation and validation.].

Objectives: The study presents the French validation of the scale of Need for Recovery after work (Need for Recovery) as well as the average scores according to sex, age, occupation and branch of industry.

Method: A representative sample of the French employees completed a questionnaire made up of the Need for Recovery Scale, Perceived Stress Scale, Hospital Anxiety and Depression Scale and Maslach Burnout Inventory - General Survey. Analyses of internal consistency led us to withdraw an item from original scale; validity as well as discriminating quality were evaluated with the adequate analyses.