Publications by authors named "Lebin Han"
Two genotypes of H3N2 swine influenza viruses identified in pigs from Shandong Province, China.
Front Cell Infect Microbiol
January 2025
Swine influenza virus (SIV) is a highly contagious pathogen that poses significant economic challenges to the swine industry and carries zoonotic potential, underscoring the need for vigilant surveillance. In this study, we performed a comprehensive genetic and molecular analysis of H3N2 SIV isolates obtained from 372 swine samples collected in Shandong Province, China. Phylogenetic analysis revealed two distinct genotypes.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is an important swine pathogen that has caused considerable economic losses in the global swine industry. During our surveillance of pigs in Shandong, China, from 2018 to 2020, we found that the PCV2 infection rate was 7.89% (86/1090).
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- Swine influenza viruses (SIVs) are present globally and pose health risks to humans, particularly a recently identified G4 genotype H1N1 strain from surveillance in Shandong Province, China (2019-2022).
- The G4 H1N1 strain has unique mutations that enhance its ability to bind to human cells and increase its pathogenicity in mice, indicating it could effectively infect humans.
- The isolated viruses led to severe respiratory and neurological issues in mice, suggesting a need for intensified monitoring to better understand their potential for causing a pandemic.
Background: Swine influenza A virus (IAV-S) is a common cause of respiratory disease in pigs and poses a major public health threat. However, little attention and funding have been given to such studies. The aim of this study was to assess the prevalence of the Eurasian avian-like H1N1 (EA H1N1), 2009 pandemic H1N1 (pdm/09 H1N1), and H3N2 subtype antibodies in unvaccinated swine populations through serological investigations.
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