Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.

Schizophrenia, a severe psychiatric, neurodevelopmental disorder affecting about 0.29-1 % of the global population, is characterized by hallucinations, delusions, cognitive impairments, disorganized thoughts and speech, leading to significant social withdrawal and emotional blunting. During the 1980s, considerations about diseases that result from complex interactions of genetic background and environmental factors started to appear.

α-Klotho is associated with cardiovascular and all-cause mortality in patients with stage 3b and 4 chronic kidney disease (CKD): a long-term prospective cohort study.

Background: α-Klotho deficiency may increase cardiovascular risks and worsen survival. We evaluated the association of α-Klotho with cardiovascular and all-cause mortality in pre-dialysis chronic kidney disease (CKD) patients.

Methods: In this prospective study, 75 non-diabetic CKD stage 3b-4 patients were followed-up for a median of 8 years.

[Anemia of chronic diseases in the early stages of chronic kidney disease as a risk factor for cardiovascular complications in patients with glomerulonephritis].

Aim: To determine biomarkers of anemia of chronic disease (ACD) in patients with glomerulonephritis (GN) in the early stages of CKD, to assess their role as risk factors for cardiovascular complications (CVС).

Materials And Methods: Seventy nine patients with GN were studied, among them: 40 with primary сhronic GN (CGN), 39 with secondary forms:19 - GN with ANCA-associated systemic vasculitis, 20 - GN with systemic lupus erythematosus (SLE) at early (all I-II) CKD stages. In all patients, the level of serum C-reactive protein (CRP), hepcidin, interferon γ, and the circulating form of protein Klotho (s-Klotho) were determined.

CRISPR/Cas9-Mediated Knock-Out of the Gene Highlights Its Key Role in the Control of Symbiotic Nodule Numbers under High-Nitrate Conditions.

Legume plants have the ability to establish a symbiotic relationship with soil bacteria known as rhizobia. The legume-rhizobium symbiosis results in the formation of symbiotic root nodules, where rhizobia fix atmospheric nitrogen. A host plant controls the number of symbiotic nodules to meet its nitrogen demands.

A dataset of microstructure features and physicochemical properties of soils of the solonetzic complex in 2022 (Caspian lowland).

The fact of global climate change is generally recognized by the world scientific community. However, the spatial distribution of climatic parameters is very heterogeneous. In this regard, studies of the local response of individual territories to global climate change are of particular importance.

Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid.

Potato virus Y (PVY) is one of the most dangerous agricultural pathogens that causes substantial harm to vegetative propagated crops, such as potatoes (Solanum tuberosum L.). A necessary condition for PVY infection is an interaction between the plant cap-binding translation initiation factors eIF4E and a viral protein VPg, which mimics the cap-structure.

Acute Kidney Injury in Hospitalized Patients with COVID-19: Risk Factors and Serum Biomarkers.

Background: AKI is one of the COVID-19 complications with high prognostic significance. In our research, we studied the prognostic role of several biomarkers that could help us understand AKI pathogenesis in patients with COVID-19.

Methods: We evaluated the medical data of 500 patients hospitalized with COVID-19 in Tareev Clinic from 5 October 2020 to 1 March 2022.

[Anti-Restriction Activity of ArdB Protein against EcoAI Endonuclease].

ArdB proteins are known to inhibit the activity of the type I restriction-modification (RM-I) system, in particular EcoKI (IA family). The mechanism of ArdB's activity still remains unknown; the spectrum of targets inhibited has been poorly studied. In this work, it was shown that the presence of the ardB gene from the R64 plasmid could suppress the activity of EcoAI endonuclease (IB family) in Escherichia coli TG1 cells.

Is it possible to predict postoperative blood loss in surgery for idiopathic scoliosis?

Introduction: Postoperative drain loss can exceed intraoperative blood loss and affect the severity of the patient's condition. Aim: The objective of the study was to find significant predictors of postoperative blood loss in surgery for idiopathic scoliosis.

Materials And Methods: We analyzed the data of 140 patients with idiopathic scoliosis.

A dataset of soil microstructure features and physicochemical properties for 1968 and climate sequence for 1951-1992 in the Caspian lowland.

The soils of arid regions are sensitive to short-term climate changes, which are most quickly manifested in the saline state of alkaline and saline soils. Long-term climate changes are reflected in more stable soil characteristics, such as grain size distribution and microstructure. These properties can be used as indicators to assess the direction and degree of soil transformation under the influence of climate change in the longer term.

How temperature-dependent silicate weathering acts as Earth's geological thermostat.

Earth's climate may be stabilized over millennia by solubilization of atmospheric carbon dioxide (CO) as minerals weather, but the temperature sensitivity of this thermostat is poorly understood. We discovered that the temperature dependence of weathering expressed as an activation energy increases from laboratory to watershed as transport, clay precipitation, disaggregation, and fracturing increasingly couple to dissolution. A simple upscaling to the global system indicates that the temperature dependence decreases to ~22 kilojoules per mole because (i) the lack of runoff limits weathering and retains base metal cations on half the land surface and (ii) other landscapes are regolith-shielded and show little weathering response to temperature.

Effects of Vertically Heterogeneous Soil Salinity on Genetic Polymorphism and Productivity of the Widespread Halophyte .

Salinity is one of the environmental factors that affects both productivity and genetic diversity in plant species. Within the soil profile, salinity is a dynamic indicator and significantly changes with depth. The present study examined the effects of the vertical heterogeneity of soil salinity chemistry on the plant height, fresh and dry biomass accumulation, water content, level of genetic polymorphism, and observed and expected heterozygosity in seven populations of halophyte in natural habitats.

Local and systemic targets of the MtCLE35-SUNN pathway in the roots of Medicago truncatula.

CLE (CLAVATA3/ENDOSPERM SURROUNDING REGION-related) peptides are systemic regulators of legume-rhizobium symbiosis that negatively control the number of nitrogen-fixing nodules. CLE peptides are produced in the root in response to rhizobia inoculation and/or nitrate treatment and are transported to the shoot where they are recognized by the CLV1-like (CLAVATA1-like) receptor kinase. As a result, a shoot-derived signaling pathway is activated that inhibits subsequent nodule development in the root.

Identification and Expression Analysis of the Family in L.

The (CEP) peptides play crucial roles in plant growth and response to environmental factors. These peptides were characterized as positive regulators of symbiotic nodule development in legume plants. However, little is known about the CEP peptide family in pea.

Assessment of academic achievements in m-learning.

The paper analyzes the teaching experiment regarding the use of mobile apps in the assessment of student learning. The study involved survey and self-description methods offered to students and instructors to assess the effectiveness of using mobile apps in learning. The study was conducted among 320 s-year students of the I.

Development of potato (Solanum tuberosum L.) plants with StLEAFY knockout.

StLFY-knockout potato plants were developed using CRISPR/Cas9 system. Inflorescences of edited plants transited to flowering, but inflorescence structures lacked flowers and were indeterminate, producing multiple shoot meristems. The tetraploid potato (Solanum tuberosum L.

[Diagnostic and treatment difficulties in kidney damage in the patient with generalized sarcoidosis during COVID-19. Case report].

The presented clinical observation reflects the difficulties of differential diagnosis of progressive kidney damage in a patient with sarcoidosis who has undergone a new coronavirus infection. The differential circle included interstitial nephritis as an exacerbation of the underlying disease, acute drug-induced kidney injury, acute glomerulonephritis. Nephrobiopsy confirmed the diagnosis of acute sarcoid tubulointerstitial nephritis with acute tubular necrosis.

Ordering motivation and Likert scale ratings: When a numeric scale is not necessarily better.

Measuring psychological attributes, such as motivation, typically involves rating scales, assuming that an attribute can be ordered, and that ratings represent this order. Previously, only the first assumption had been tested, albeit limited. First, we checked the ordinal structure of motivation, looking at whether people can establish transitive relations between motivation levels in pairwise comparisons; and we found different ordering patterns: strict transitive, weak transitive, changing order, and intransitivity.

Creating a list of word alignments from parallel Russian simplification data.

This work describes the development of a list of monolingual word alignments taken from parallel Russian simplification data. This word lists can be used in such lexical simplification tasks as rule-based simplification applications and lexically constrained decoding for neural machine translation models. Moreover, they constitute a valuable source of information for developing educational materials for teaching Russian as a second/foreign language.

Vascular plants occurrences in the Southern Urals industrial towns (Sterlitamak and Salavat).

Background: The paper presents datasets of plant species of two industrial cities Sterlitamak and Salavat (Republic of Bashkortostan) is presented. These cities are part of the Southern Bashkortostan urban agglomeration and are amongst the three largest in the Republic. The population of Sterlitamak is about 276,000.

[Current concepts about autonomic dysfunction in patients with epilepsy].

Autonomic dysfunction is frequently observed in people with epilepsy. Ictal and postictal dysautonomia is not only manifestation of autonomic seizures, but could be a life threatening condition in some cases and contribute to sudden unexpected death (SUDEP). Interictal decrease of autonomic activity is associated with duration and severity of epilepsy, it is the most prominent in focal and drug-resistant epilepsy.