RNA Polymerase Inhibitor Enisamium for Treatment of Moderate COVID-19 Patients: A Randomized, Placebo-Controlled, Multicenter, Double-Blind Phase 3 Clinical Trial.

Enisamium is an orally available therapeutic that inhibits influenza A virus and SARS-CoV-2 replication. We evaluated the clinical efficacy of enisamium treatment combined with standard care in adult, hospitalized patients with moderate COVID-19 requiring external oxygen. Hospitalized patients with laboratory-confirmed SARS-CoV-2 infection were randomly assigned to receive either enisamium (500 mg per dose, four times a day) or a placebo.

Extended Defects in Graphene and Their Contribution to the Excess Specific Heat at High Temperatures.

The recent experiments on fast (microsecond) pulse heating of graphite suggest the existence of sharp maximum (6500 K at 1-2 GPa) on its melting curve. To check the validity of these findings, we propose to investigate the accumulation of extended in-plane defects in graphene. Such defects would contribute to thermodynamic properties of graphene and impose the upper limit on its melting temperature.

Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial.

Pandemic SARS-CoV-2 causes a mild to severe respiratory disease called Coronavirus Disease 2019 (COVID-19). Control of SARS-CoV-2 spread will depend on vaccine-induced or naturally acquired protective herd immunity. Until then, antiviral strategies are needed to manage COVID-19, but approved antiviral treatments, such as remdesivir, can only be delivered intravenously.

Pure purr virtual reality technology: measuring heart rate variability and anxiety levels in healthy volunteers affected by moderate stress.

Introduction: Traditional approaches to stress management are difficult to learn and to implicate in daily life. Emerging technologies like virtual reality (VR) have become a target of extensive study for recreational and medical purposes. The autonomic nervous system (ANS) plays a crucial role in stress response, post-stress relaxation, and recovery.

Structure and topology of three-dimensional hydrocarbon polymers.

A new family of three-dimensional hydrocarbon polymers which are more energetically favorable than benzene is proposed. Although structurally these polymers are closely related to well known diamond and lonsdaleite carbon structures, using topological arguments we demonstrate that they have no known structural analogs. Topological considerations also give some indication of possible methods of synthesis.

Fluctuation-dissipation theorem and the dielectric response in supercooled liquids.

We consider the correlation between static conductivity and dynamic dielectric relaxation in a number of polar organic liquids. Experimental evidence suggests that in the simple cases the linear dependence between characteristic frequency of relaxation process and the value of static susceptibility is observed. However, this proportionality can be broken due to the appearance of additional relaxation processes (secondary or high-frequency ones) so it can be confused with the "fractional" variant of Debye-Stokes-Einstein relation.

Phase transformations in methanol at high pressure measured by dielectric spectroscopy technique.

The dielectric response in methanol measured in wide pressure and temperature ranges (P < 6.0 GPa; 100 K < T < 360 K) reveals a series of anomalies which can be interpreted as a transformation between several solid phases of methanol including a hitherto unknown high-pressure low-temperature phase with the stability range P > 1.2 GPa and T < 270 K.

Electrotransport and magnetic properties of Cr-GaSb phases synthesized under high pressure.

The electrotransport and magnetic properties of new phases in the Cr-GaSb system were studied. The samples were prepared by high-pressure (P=6-8 GPa), high-temperature treatment and identified by x-ray diffraction and scanning electron microscopy. One of the CrGa(2)Sb(2) phases with an orthorhombic structure Iba2 has a combination of ferromagnetic and semiconductor properties and is potentially promising for spintronic applications.

Remodeling of ammon's horn during the first two weeks of experimental diabetes development.

It is known that long-term diabetes mellitus causes hippocampal dysfunction, however, early events leading to diabetes-related impairments of hippocampal tissue remain obscure. The present study was performed to examine temporal and spatial patterns of neuronal damage and astrogliosis in hippocampal CA1-C3 areas during the early stage of streptozotocin-induced diabetes in rats. NeuN and GFAP immunohistochemistry was used to visualize neurons and glial cells.

Early reaction of astroglial cells in rat hippocampus to streptozotocin-induced diabetes.

Diabetic patients show impaired brain functions, although underlying mechanisms remain unclear. Little is known as well about early diabetes-related changes in a brain tissue. To investigate them we analyzed the reaction of astroglial cells in the hippocampus of rats rendered diabetic by a single injection of streptozotocin (STZ).