Publications by authors named "Leanne Toube"
Article Synopsis
- - NF-kappaB transcription factors play a crucial role in activating genes that are essential for the immune response, inflammation, and cell survival, interacting with transcription elongation factors P-TEFb and DSIF.
- - The study reveals that NF-kappaB regulates different target genes through either P-TEFb or DSIF depending on the type of core promoter (TATA or TATA-less) and enhancer present in the gene.
- - The conversion of a TATA-less promoter to a TATA promoter shifts regulatory control from DSIF to P-TEFb, with RNA polymerase II phosphorylation by P-TEFb facilitating this change, thereby linking transcription initiation and elongation processes.
Regulation of mutation rates is critical for maintaining genome stability and controlling cancer risk. A special challenge to this regulation is the presence of multiple mutagenic DNA polymerases in mammals. These polymerases function in translesion DNA synthesis (TLS), an error-prone DNA repair process that involves DNA synthesis across DNA lesions.
View Article and Find Full Text PDFPax6 transcription factor is required for islet cell number, morphology, and hormone gene expression. The perinatal lethality of Pax6 null mutants has restricted investigation of the role of Pax6 in normal endocrine cell function. Therefore, we devised the conditional inactivation of Pax6 using the Pdx1 and Pax6 regulatory domains to activate Cre in cells of either the entire pancreatic bud or only in endocrine cell lineages, respectively.
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