Publications by authors named "Leanne Santarelli"
Purpose: The use of centralized systems to adjudicate clinical events is common in large clinical trials, in spite of relatively little published literature concerning the rationale and justification. The purpose of this manuscript is to review the reasons for central adjudication and to discuss whether trials could be simplified by limiting or streamlining the adjudication process.
Methods: We reviewed the literature concerning central adjudication and documented the experience of adjudication in several clinical trials.