Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity.

Objective: Time-restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this in humans is limited. The objective of this study was to investigate the effects of TRE on 24-hour profiles of plasma metabolites, glucoregulatory hormones, and the subcutaneous adipose tissue (SAT) transcriptome in humans.

Methods: Men (n = 15, age = 63 [4] years, BMI 30.

Time-restricted eating improves glycemic control and dampens energy-consuming pathways in human adipose tissue.

Objective: We sought to examine the effects of 8 wk of time-restricted eating (TRE) on glucose metabolism and the adipose tissue transcriptome during a metabolic ward stay in men with obesity.

Methods: In a single-arm, pre-post trial, 15 men (ages 63 ± 4 y, body mass index = 30.5 ± 2.

Efficacy of methotrexate in polymyalgia rheumatica in routine rheumatology clinical care.

Background: Current guidelines recommend methotrexate (MTX) as a glucocorticoid-sparing agent in patients with polymyalgia rheumatica (PMR) who relapse or suffer glucocorticoid adverse effects, although there is no level 1 evidence to support this recommendation.

Aims: To review the effect of MTX in PMR on inflammation and glucocorticoid dose.

Methods: Patients with PMR from rheumatology outpatient clinics at two tertiary centres were identified.

Risk of mortality in patients with giant cell arteritis: A systematic review and meta-analysis.

Background: Previous studies of mortality associated with GCA have shown conflicting results. We conducted a systematic review and meta-analysis to determine the mortality risk in GCA patients compared to the general population.

Methods: We searched for published studies indexed in MEDLINE and EMBASE and the Cochrane database from inception to June 18, 2015 using the terms "giant cell arteritis" and "temporal arteritis" combined with the terms for death, mortality, and survival.

Acute red eye (non-ulcerative keratitis) associated with mini-scleral contact lens wear for keratoconus.

Mini-scleral lenses are an increasingly popular contact lens modality; however, there are relatively few reports regarding the unique aspects of their fitting and potential complications. We report a complication of mini-scleral lens wear in a 44-year-old female patient using the lenses for keratoconus. Her mini-scleral contact lenses were non-fenestrated and fitted to vault over the cornea and seal at the periphery.