Publications by authors named "Leanne Logan"
Article Synopsis
- Orthopneumoviruses create membrane-less cytoplasmic inclusion bodies (IBs) that aid in the replication, transcription, and translation of their RNA by sequestering translation machinery components within these structures.
- Studies on respiratory syncytial virus (RSV) showed that these inclusion bodies have a bi-phasic structure with distinct functional domains, including granules that concentrate viral mRNA and translation initiation factors.
- The viral M2-1 protein plays a crucial role by interacting with essential translation factors, facilitating their transport and supporting a unique translation environment within the inclusion bodies, even suggesting the presence of ribosomes for translation within these structures.
SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses circulating in bats, SARS-CoV-2 is thought to have originated in Chiroptera species in China. However, whether the virus spread directly to humans or through an intermediate host is currently unclear, as is the potential for this virus to infect companion animals, livestock, and wildlife that could act as viral reservoirs.
View Article and Find Full Text PDFThe measles virus (MeV), a member of the genus , is an established pathogen of humans. A key feature of morbilliviruses is their ability to spread by virus-cell and cell-cell fusion. The latter process, which leads to syncytia formation in vitro and in vivo, is driven by the viral fusion (F) and haemagglutinin (H) glycoproteins.
View Article and Find Full Text PDFBackground: The purpose of this report is to present a model of physicians in full-time clinical practice participating as investigators in multicenter clinical trials, sponsored by a pharmaceutical or medical device company.
Methods: This gas-exchange substudy was conducted as a pilot study to establish the feasibility of the 10-member EXERcise testing group of the Duke University Cooperative Cardiovascular Society (EXERDUCCS) consortium to perform a complex multicenter trial using cardiopulmonary exercise testing. An active interchange of information was established involving the principal investigator for the substudy, a dedicated full-time project coordinator, a medical director of the overall EXERDUCCS network site, the project coordinator for the sponsor, and all the participating EXERDUCCS investigators and coordinators.
Purpose/objectives: This study explored the practice of clinical nurse specialists (CNSs) certified in Community Health nursing in the United States and described demographic and employment characteristics and perspectives about professional practice.
Methods: The survey method was used. Of the 209 Community Health CNSs certified by American Nurses Credentialing Center (ANCC) invited to complete the investigator-designed mail questionnaire, 111 (53%) returned a completed questionnaire.