Assessing the impact of introducing trainee advanced clinical practitioners onto an acute oncology triage unit.

Advanced clinical practitioners (ACPs) have largely been based within acute emergency areas such as emergency departments (EDs) and acute medical units. At The Royal Wolverhampton NHS Trust, ACPs are a new element within oncology services. The acute oncology triage unit sees patients who have received systemic anti-cancer therapy (SACT) presenting with a variety of side effects and symptoms including oncological emergencies, reducing the need for ED attendance.

Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473.

The syntheses of [PtCl(2)(amp)] (amp = 2-pyridylmethylamine) and enantiomerically pure [PtCl(2)(R-pea)] and [PtCl(2)(S-pea)] (pea = 1-(2-pyridyl)ethylamine) and the crystal structure of [PtCl(2)(R-pea)] are reported. The reactions of [PtCl(2)(amp)] and of the enantiomers of [PtCl(2)(pea)] with d(GpG) and with a 52-base-pair oligonucleotide were investigated. Each of the reactions with d(GpG) resulted in the formation of three platinated bifunctional d(GpG) species in a ratio of 1:2:1.