Super-resolution imaging reveals three-dimensional folding dynamics of the β-globin locus upon gene activation.

The chromatin architecture is constantly changing because of cellular processes such as proliferation, differentiation and changes in the expression profile during gene activation or silencing. Unravelling the changes that occur in the chromatin structure during these processes has been a topic of interest for many years. It is known that gene activation of large gene loci is thought to occur by means of an active looping mechanism.

Force coordination in static bimanual manipulation: effect of handedness.

The purpose of this study was to explore the effects of handedness on coordination of grip (G) and load (L) forces in static bimanual manipulation tasks. Participants (N = 10) exerted various L profiles against an externally fixed hand-held device based on presumably open-loop and closed-loop neural control mechanisms, (i.e.