Publications by authors named "Leann To"

Background: Heavy alcohol consumption-associated chemosensory dysfunction is understudied, and early detection can help predict disease-associated comorbidities, especially those related to four quality of life (QOL) domains (physical, psychological, social and environment). We examined self-reports of chemosensory ability of individuals with different alcohol drinking behaviors and their association with changes in QOL domains.

Methods: Participants (n = 466) were recruited between June 2020 and September 2021 into the NIAAA COVID-19 Pandemic Impact on Alcohol study.

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Article Synopsis
  • Small regulatory RNAs (sRNAs), associated with the RNA chaperone Hfq, play a crucial role in regulating various bacterial functions such as metabolism, stress response, and virulence through their effect on mRNA stability and translation.
  • Researchers conducted a fluorescence-based functional screen to identify regulators that diminish the signaling of the iron-responsive sRNA RyhB, discovering both general regulators that affect multiple sRNAs and specific regulators for RyhB.
  • Among the identified specific regulators, AspX represses RyhB signaling through an RNA sponging mechanism, while YicC promotes RyhB degradation with the help of the enzyme PNPase, highlighting the complex regulatory networks involved in bacterial iron homeostasis.
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