Publications by authors named "Leandro Sierra"
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major cause of cancer deaths, often linked to chronic liver disease, but extrahepatic factors also play a significant role in its development.
- * A review of literature up to October 2024 finds that prevention strategies include hepatitis vaccinations, antiviral treatments, lifestyle changes (like diet and exercise), environmental controls, and regular screenings for high-risk groups.
- * A holistic approach that integrates medical, lifestyle, and environmental strategies is crucial for effectively reducing HCC incidence worldwide.
The cornerstone treatment for primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), but many patients exhibit an incomplete response, leading to disease progression. Risk prediction models like the GLOBE and UK-PBC scores hold promise for patient stratification and management. We aimed to independently assess the predictive accuracy of these risk scores for UDCA response in a prospective U.
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- Autoimmune liver diseases (AILDs) like autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis show varied survival rates post-liver transplant (LT), influenced by factors such as disease severity and socio-economic conditions.
- Analyzing data from 13,702 AILD patients listed for LT from 2002 to 2021, the study focused on waitlist removal, patient survival, and graft survival, taking into account demographics, health conditions, and social factors.
- Findings revealed that lack of college education and public insurance increased waitlist removal and negatively affected both patient and graft survival, while unemployment had the most significant adverse effect on survival outcomes; U.S. citizenship status did not impact
Primary biliary cholangitis (PBC) prompts liver transplantation (LT) due to cholestasis, cirrhosis, and liver failure. Despite lower MELD scores, recent studies highlight higher PBC waitlist mortality, intensifying the need for alternative transplantation strategies. Living donor liver transplant (LDLT) has emerged as a solution to the organ shortage.
View Article and Find Full Text PDFPrimary sclerosing cholangitis (PSC) is the leading indication of liver transplantation (LT) among autoimmune liver disease patients. There is a scarcity of studies comparing survival outcomes between living-donor liver transplants (LDLT)s and deceased-donor liver transplants (DDLTs) in this population. Using the United Network for Organ Sharing database, we compared 4679 DDLTs and 805 LDLTs.
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