Liquid-liquid phase separation of tau and α-synuclein: A new pathway of overlapping neuropathologies.

Liquid-liquid phase separation (LLPS) is a critical phenomenon that leads to the formation of liquid-like membrane-less organelles within cells. Advances in our understanding of condensates reveal their significant roles in biology and highlight how their dysregulation may contribute to disease. Recent evidence indicates that the high protein concentration in coacervates may lead to abnormal protein aggregation associated with several neurodegenerative diseases.

Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies.

Tauopathies and synucleinopathies are characterized by the aggregation of Tau and α-synuclein (AS) into amyloid structures, respectively. Individuals with these neuropathies have an elevated risk of developing subsequent neurodegenerative or comorbid disorders. Intriguingly, post-mortem brain examinations have revealed co-localization of Tau and AS aggregates, suggesting a synergistic pathological relationship with an adverse prognosis.

Modulation of α-synuclein phase separation by biomolecules.

Liquid-liquid phase separation (LLPS) is currently recognized as a common mechanism involved in the regulation of a number of cellular functions. On the other hand, aberrant phase separation has been linked to the biogenesis of several neurodegenerative disorders since many proteins that undergo LLPS are also found in pathological aggregates. The formation of mixed protein coacervates may constitute a risk factor in overlapping neuropathologies, such as Parkinson's (PD) and Alzheimer's (AD) diseases.

ORBI Score Validation as Predictor of Cardiogenic Shock in Patients With St Elevation Myocardial Infarction in Two Medical Centers in Argentina.

Cardiogenic shock(CS) after ST-segment elevation myocardial infarction(STEMI) has an in-hospital mortality of 50%. The ORBI score identifies patients at risk of CS after primary angioplasty. We aim to validate the score in an Argentinian cohort.

State estimation and nonlinear tracking control simulation approach. Application to a bioethanol production system.

Tracking control of specific variables is key to achieve a proper fermentation. This paper analyzes a fed-batch bioethanol production process. For this system, a controller design based on linear algebra is proposed.

Physiologic Voice Rehabilitation Based on Water Resistance Therapy With Connected Speech in Subjects With Vocal Fatigue.

Purpose: The present study aimed to assess the effectiveness of a physiologic voice therapy program based on water resistance therapy (WRT) exercises including connected speech in a group of subjects with voice complaints (vocal effort and fatigue).

Methods: Twenty-four participants with behavioral dysphonia were randomly assigned to one of two treatment groups: (1) voice treatment with WRT plus vocal hygiene program (n = 12), and (2) vocal hygiene program only (n = 12). Laryngoscopic assessment was performed in all subjects.

Clinical features and possible founder mutation of the 8bp duplication mutation in the SLC4A11 gene causing corneal dystrophy and perceptive deafness in three South American families.

Background: Corneal Dystrophy and Perceptive Deafness (CDPD) or Harboyan syndrome is an autosomal recessive rare disorder, characterized by congenital corneal opacities and progressive sensorineural hearing loss, which usually begins after the second decades of life. This study reports the ophthalmic, audiological and genetic features, in five CDPD affected patients from three Chilean families.

Materials And Methods: Five individuals affected with CDPD from three unrelated Chilean families were clinically and genetically examined.

[Clopidogrel versus prasugrel in acute coronary syndrome treated with coronary angioplasty].

Greater antithrombotic potency new antiplatelet agents have been added such as prasugrel (PR) and ticagrelor to the traditional use of clopidogrel (CL) in the treatment of acute coronary syndrome (ACS). This study was aimed at comparing the incidence of long term ischemic and hemorrhagic events in patients treated with CL or PR during hospitalization. Retrospective ACS data base analysis performed by our cardiology service was completed prospectively.

Conversion of Recent-Onset Atrial Fibrillation: Which Drug is the Best?

Vernakalant is a new, safe and effective drug used intravenously. It has proven to be more rapid in converting recent onset atrial fibrillation (AF) to sinus rhythm compared to placebo, amiodarone, propafenone and flecainide in clinical studies with few patients. At present no study has been conducted comparing these three drugs with a more substantial number of patients.

[Operating room extubation (ultra fast-track anesthesia) in patients undergoing on-pump and off-pump cardiac surgery].

Objective: The potential benefit of immediate operating room extubation after cardiac surgery remains controversial. Since safety and effectiveness of ultra fast-track anesthesia is mandatory, we developed this work to identify preoperative and operative variables associated to failed extubation after on-pump and off-pump cardiac surgery.

Methods: Three hundred ninety eight consecutive patients undergoing coronary, valve or combined surgery were included in a prospective observational study of ultra fast-track anesthesia.

Relationship of high pretreatment folic acid level and failure of methotrexate in ectopic pregnancy: a pilot study.

Objective: To test the hypothesis that high (> or =20.7 ng/mL) pretreatment serum folic acid level increases the failure of single-dose methotrexate for ectopic pregnancy.

Study Design: Twenty patients with ectopic pregnancy and measured pretreatment folic acid levels were divided into 2 groups based on pretreatment serum folic acid level (< or > or =20.