Publications by authors named "Leandro Layter Xavier"
Dengue is a re-emerging disease, currently considered the most important mosquito-borne arbovirus infection affecting humankind, taking into account both its morbidity and mortality. Brazil is considered an endemic country for dengue, such that more than 1,544,987 confirmed cases were notified in 2019, which means an incidence rate of 735 for every 100 thousand inhabitants. Climate is an important factor in the temporal and spatial distribution of vector-borne diseases, such as dengue.
View Article and Find Full Text PDFEvidences of HEV genotype 3 persistence and reactivity in liver parenchyma from experimentally infected cynomolgus monkeys (Macaca fascicularis).
Diana Chaves Pereira Mejido Jaqueline Mendes de Oliveira Ana Maria Coimbra Gaspar Noemi Rovaris Gardinali Fernanda de Oliveira Bottino Leandro Layter Xavier
PLoS One
February 2020
Article Synopsis
- HEV-3 is a zoonotic virus causing acute hepatitis E, and primate models help study its effects.
- Eight cynomolgus macaques were inoculated with HEV-3 to analyze the viral impact over 67 days, revealing a complex recovery phase.
- While some biochemical signs normalized by 55 days, lingering HEV RNA and antigen were found in organs afterwards, suggesting the potential for chronic infections and risks in liver transplants.