Publications by Leandro Cenesi

Publications by authors named "Leandro Cenesi"

J Alzheimers Dis

April 2022

The study examines the role of cerebrospinal fluid (CSF) biomarkers, like amyloid-β and tau proteins, in diagnosing Alzheimer's disease (AD), particularly during its preclinical phases, such as mild cognitive impairment.
There are ongoing debates about the reliability and clinical utility of these biomarkers, particularly whether they can accurately diagnose AD without accompanying clinical symptoms.
The authors advocate for a balanced approach to AD diagnosis, emphasizing the importance of considering both clinical observations and biological markers together.

- Leandro Cenesi's recent research focuses on the evaluation of cerebrospinal fluid (CSF) biomarkers used in the diagnosis and understanding of Alzheimer's disease (AD), emphasizing their significance in both clinical and preclinical phases of the disease.
- His article discusses the standard biomarkers in AD research, including amyloid-β plaques, p-tau, and t-tau, while questioning the clarity of their roles specifically in preclinical stages of diagnosis and the methodologies used for their assessment.
- The findings highlight the increasing application of CSF biomarkers in routine clinical practice, but also address the complexities and considerations surrounding the cost-benefit analysis of these tests in relation to AD management.