High-Flow Oxygen and Other Noninvasive Respiratory Support Therapies in Bronchiolitis: Systematic Review and Network Meta-Analyses.

Objectives: We present a systematic review on the effectiveness of noninvasive respiratory support techniques in bronchiolitis.

Data Sources: Systematic review with pairwise meta-analyses of all studies and network meta-analyses of the clinical trials.

Study Selection: Patients below 24 months old with bronchiolitis who require noninvasive respiratory support were included in randomized controlled trials (RCTs), non-RCT, and cohort studies in which high-flow nasal cannula (HFNC) was compared with conventional low-flow oxygen therapy (LFOT) and/or noninvasive ventilation (NIV).