Publications by authors named "Leandro C Santos"
Lancet Infect Dis
October 2024
Article Synopsis
- The study explores the resurgence of Oropouche fever in Brazil from 2023 to 2024, focusing on virological factors influencing the outbreak after decades of sporadic cases.
- Researchers gathered data from various sources, analyzed serum samples from patients and previously infected individuals, and performed molecular tests to understand the virus's characteristics and behavior.
- The findings showed an extraordinary spike in cases in 2024, with over 8,600 confirmed incidents, highlighting the virus's widespread distribution across all regions of Brazil.
Article Synopsis
- * The study included data from 2015 to 2024, revealing a dramatic rise in infections—83.2% occurring in the North—and identified a novel OROV strain that is much more virulent than the original prototype.
- * The new OROV strain was shown to replicate significantly faster and more effectively in mammalian cells, with a notable decrease in neutralizing antibodies from individuals previously infected, indicating a potential threat to public health.
