Publications by authors named "Leandre Mutimbwa-Mambo"
Article Synopsis
- The text discusses the historical context of monkeypox outbreaks originating from different clades in Africa, particularly focusing on a recent outbreak in the Democratic Republic of the Congo caused by clade I MPXV.
- Surveillance data collected from September 2023 to January 2024 identified 241 suspected cases, with genomic analysis revealing a new lineage distinct from prior strains in the area.
- The median age of confirmed cases was 22 years, with a significant portion being female and sex workers, hinting at potential sexual transmission; ongoing mutations suggest recent human-to-human spread.
Introduction: Human Mpox (formerly monkeypox) infection is an emerging zoonotic disease caused by the Mpox virus (MPXV). We describe the complete genome annotation, phylogeny, and mutational profile of a novel, sustained Clade I Mpox outbreak in the city of Kamituga in Eastern Democratic Republic of the Congo (DRC).
Methodology: A cross-sectional, observational, cohort study was performed among patients of all ages admitted to the Kamituga Hospital with Mpox infection symptoms between late September 2023 and late January 2024.
Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage.
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