Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches.

Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests.

Comparison of explosive force between young and elderly women: evidence of an earlier decline from explosive force.

The aging process causes many changes in muscle strength, and analysis of explosive force from handgrip strength seems to be useful and promising in studying the aging musculoskeletal system. Therefore, the purpose of this study was to investigate if explosive force parameters [rate of force development (RFD) and contractile impulse (CI) over the time interval of 0-200 ms from the onset of contraction] during handgrip efforts decline differently than maximum handgrip strength with increasing age. Twenty healthy young women (20-27 years) and 65 healthy elderly women, assigned into three age groups (50-64, 65-74, and 75-86 years), participated in this study.

Antinociceptive and anti-inflammatory effects of the monoterpene α,β-epoxy-carvone in mice.

α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects.

Antinociceptive and toxicological effects of Dioclea grandiflora seed pod in mice.

The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid-induced writhing test and the formalin test. The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phases in the formalin test. The hot plate test did not show an increase in the antinociceptive latency whereas the motor performance was affected by the administration at 300 mg/kg at the beginning (30 minutes) of the observation period but not at later periods (60 and 120 minutes).