Publications by authors named "Lealia L Xiong"
Article Synopsis
- Engineered living materials (ELMs) utilize living components that can grow, repair, and respond to stimuli, with E. coli as a key element due to its genetic engineering capabilities and rapid growth rates.
- A new genetic circuit was created to regulate E. coli pigmentation based on temperature, allowing these bacteria to adapt their growth strategies; they enhance pigmentation below 36 °C to boost temperature and growth rates, while decreasing pigmentation above this threshold to protect against heat stress.
- This innovation aims to improve the efficiency of ELMs by optimizing the performance of E. coli for better growth and protein production under varying seasonal temperatures.
Article Synopsis
- Temperature is an important factor for controlling gene expression in engineered cells, with most studies focusing on heat-induced methods.
- Research introduces temperature-sensitive transcriptional activators, specifically mutant forms of the Lambda phage repressor CI, which can activate gene expression through cooling at specified temperatures.
- The study demonstrates that these activators can function as both repressors and activators within the same genetic system, enhancing the ability to manipulate cellular functions with temperature variations.
Mycobacterium tuberculosis remains a leading cause of death worldwide, especially among individuals infected with HIV. Whereas phylogenetic analysis has revealed M. tuberculosis spread throughout history and in local outbreaks, much less is understood about its dissemination within the body.
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