Inheritance of cerebellar abiotrophy in Arabians.

Objective: To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians.

Animals: 804 Arabians, including 29 horses (15 males and 14 females) with CA.

Procedures: Most horses (n = 755) belonged to 1 of 4 paternal families.

Mapping of equine cerebellar abiotrophy to ECA2 and identification of a potential causative mutation affecting expression of MUTYH.

Equine Cerebellar Abiotrophy (CA) is a neurological disease found in Arabian horses. CA is characterized by post-natal degeneration of the Purkinje cells of the cerebellum. Signs of CA include ataxia, head tremors, and a lack of balance equilibrium.

Azoospermia associated with bilateral segmental aplasia of the ductus deferens in a stallion.

A 3-year-old Quarter Horse halter stallion was referred for routine semen evaluation. Physically, the stallion's reproductive organs appeared normal. Repeated semen evaluations did not reveal any spermatozoa.