Publications by authors named "Leah R Martin"
Article Synopsis
- Ewing sarcoma (EWS) is a type of aggressive tumor that typically affects young people but can occur at any age, and treatment options are limited for cases that recur after initial therapy.
- Recent trials testing different chemotherapy combinations have not led to better survival rates for EWS patients, highlighting a gap in effective treatments.
- Researchers have found that two drugs, enoxacin (an approved antibiotic) and entinostat (not yet approved), show promise as adjuvant therapies alongside chemotherapy, particularly recommending further study on enoxacin for EWS patients.
Sensitization of osteosarcoma to irradiation by targeting nuclear FGFR1.
Biochem Biophys Res Commun
September 2022
Over the past 25 years, chemotherapy regimens for osteosarcoma have failed to improve the 65-70% long-term survival rate. Radiation therapy is generally ineffective except for palliative care. We here investigated whether osteosarcoma can be sensitized to radiation therapy targeting specific molecules in osteosarcoma.
View Article and Find Full Text PDFDiffuse intrinsic pontine glioma (DIPG), a rare pediatric brain tumor, afflicts approximately 350 new patients each year in the United States. DIPG is noted for its lethality, as fewer than 1% of patients survive to five years. Multiple clinical trials involving chemotherapy, radiotherapy, and/or targeted therapy have all failed to improve clinical outcomes.
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