Publications by authors named "Leah Oswalt"
Article Synopsis
- Missions into Deep Space this decade are concerning due to potential health risks from microgravity and galactic cosmic radiation, especially for kidneys.
- Researchers used various biological and clinical analyses on samples from spaceflight-exposed mice, humans, and simulated environments.
- Key findings reveal that spaceflight causes kidney-related issues like increased risk of kidney stones, changes in nephron structure, and damage from radiation exposure.
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair.
DNA Repair (Amst)
July 2024
Article Synopsis
- NEIL3 is a DNA glycosylase that specializes in repairing various DNA modifications, particularly in single-strand DNA and junctions between single and double strands.
- Unlike other repair enzymes, it plays a unique role in both base excision repair and addressing interstrand DNA crosslinks, offering an alternative repair route to the Fanconi Anemia pathway.
- The review discusses NEIL3's biological functions, its implications in diseases, and its structural characteristics that affect how it interacts with and repairs damaged DNA.
Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying that hazard and whether it arises from direct inhibition of cardiomyocyte α1-ARs or from systemic effects remain unclear. To address these issues, we created a mouse with cardiomyocyte-specific deletion of the α1A-AR subtype and found that it experienced 70% mortality within 7 days of myocardial infarction driven, in part, by excessive activation of necroptosis.
View Article and Find Full Text PDFThe cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell surface abundance, we identify STUB1 as an E3 ubiquitin ligase for IFNγ-R1 in complex with its signal-relaying kinase JAK1.
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